10725819
Brain, hrr
https://raw.githubusercontent.com/jamesd4335/hrr2/master/hrr_pipes.csl
50
date
desc
185
https://healthresearchreport.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KIN7M6BN%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Moghimian%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-21%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cb%3EPreventive%20impacts%20of%20vitamin%20C%20on%20memory%20damage%20caused%20by%20unpredictable%20chronic%20mild%20stress%20in%20relation%20to%20biochemical%20parameters%20in%20the%20hippocampus%20of%20male%20rats%3C%5C%2Fb%3E%23%23%212022%20%7C%20Moghimian%20M%2C%20Azin%20S%2C%20et%20al.%20%7C%20%3Ci%3ENutritional%20Neuroscience%3C%5C%2Fi%3E.%202022%3B0%280%29%3A1-10.%20%23%23%21%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F1028415X.2022.2145423%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F1028415X.2022.2145423%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Preventive%20impacts%20of%20vitamin%20C%20on%20memory%20damage%20caused%20by%20unpredictable%20chronic%20mild%20stress%20in%20relation%20to%20biochemical%20parameters%20in%20the%20hippocampus%20of%20male%20rats%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maryam%22%2C%22lastName%22%3A%22Moghimian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sohrab%22%2C%22lastName%22%3A%22Azin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seyed%20Sajjad%22%2C%22lastName%22%3A%22Alavi%20%5Cu2013Kakhki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masoumeh%22%2C%22lastName%22%3A%22Kourosh-Arami%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masoumeh%22%2C%22lastName%22%3A%22Gholami%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farimah%22%2C%22lastName%22%3A%22Beheshti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masoumeh%22%2C%22lastName%22%3A%22Fani%22%7D%5D%2C%22abstractNote%22%3A%22The%20present%20study%20focused%20on%20examining%20the%20impact%20of%20vitamin%20C%20%28Vit%20C%29%20administration%20on%20the%20function%20of%20memory%20and%20the%20status%20of%20oxidative%20stress%20%28OS%29%20in%20the%20hippocampal%20area%20of%20the%20brain%20using%20an%20unpredictable%20chronic%20mild%20stress%20%28UCMS%29%20model%20in%20rats.%20To%20this%20end%2C%2050%20male%20Wistar%20rats%20%2811-12%20weeks%20of%20age%20at%20the%20start%20of%20the%20study%29%20were%20assigned%20to%20five%20groups%20of%20six%20animals%2C%20including%20control%2C%20UCMS%2C%20UCMS%20%2B%20Vit%20C%2050%20mg%5C%2FKg%2C%20UCMS%20%2B%20Vit%20C%20100%20mg%5C%2FKg%2C%20and%20UCMS%20%2B%20Vit%20C%20400%20mg%5C%2FKg.%20The%20animals%20received%20daily%20intraperitoneal%20injections%20of%20Vit%20C%20at%20a%20certain%20time%20%289%20am%29%20before%20the%20initiation%20of%20a%20stressor.%20UCMS%2C%20including%20a%20progression%20of%20typical%20stressors%2C%20was%20applied%20for%20four%20weeks.%20Subsequently%2C%20using%20the%20passive%20avoidance%20%28PA%29%20and%20Morris%20water%20maze%20%28MWM%29%20tests%20were%20performed%20to%20investigate%20learning%20and%20memory.%20Eventually%2C%20hippocampal%20tissues%20were%20evaluated%20in%20terms%20of%20OS%20criteria.%20The%20results%20revealed%20that%20the%20latency%20to%20enter%20the%20dark%20chamber%20%28P%20%3C%200.%2001%20and%20P%20%3C%200.05%2C%20PA%20test%29%20and%20the%20time%20spent%20in%20the%20target%20quadrant%20%28P%20%3C%200.0001%2C%20MWM%20test%29%20were%20shorter%20in%20the%20UCMS%20group%2C%20while%20latency%20to%20discover%20the%20platform%20was%20longer%20%28P%20%3C%200.05%20and%20P%20%3C%200.001%2C%20MWM%20test%29%20compared%20to%20the%20control%20group.%20However%2C%20UCMS%20decreased%20the%20content%20of%20thiol%20%28P%20%3C%200.0001%29%2C%20as%20well%20as%20the%20activities%20of%20catalase%20%28P%20%3C%200.0001%29%20and%20superoxide%20dismutase%20%28P%20%3C%200.0001%29%2C%20whereas%20the%20concentration%20of%20malondialdehyde%20%28P%20%3C%200.01%29%20increased%20in%20the%20hippocampal%20region%20of%20the%20brain%20in%20comparison%20to%20the%20control%20group.%20Interestingly%2C%20Vit%20C%20treatment%20reversed%20the%20mentioned%20effects%20of%20UCMS.%20Therefore%2C%20the%20latency%20to%20enter%20the%20dark%20chamber%20%28P%20%3C%200.%2005%20and%20P%20%3C%200.01%2C1%20and%2024%20h%20after%20the%20shock%2C%20PA%20test%2C%20UCMS%20%2B%20Vit%20C%20400%29%20and%20the%20time%20spent%20in%20the%20target%20quadrant%20%28P%20%3C%200.%2001%20and%20P%20%3C%200.05%2C%20MWM%20test%2C%20UCMS%20%2B%20Vit%20C%20400%20and%20UCMS%20%2B%20Vit%20C%20100%2C%20respectively%29%20were%20longer%20in%20the%20UCMS%20%2B%20Vit%20C%20groups.%20Moreover%2C%20Vit%20C%20increased%20the%20content%20of%20thiol%20%28P%20%3C%200.05%2C%20UCMS%20%2B%20Vit%20C%20400%29%2C%20as%20well%20as%20the%20activity%20of%20catalase%20%28P%20%3C%200.001%2C%20UCMS%20%2B%20Vit%20C%20400%29%20and%20superoxide%20dismutase%20%28P%20%3C%200.0001%2C%20UCMS%20%2B%20Vit%20C%20400%2C%20UCMS%20%2B%20Vit%20C%20100%29%2C%20whereas%20the%20concentration%20of%20malondialdehyde%20%28P%20%3C%200.%2005%20and%20P%20%3C%200.01%2C%20UCMS%20%2B%20Vit%20C%20100%2C%20UCMS%20%2B%20Vit%20C%20400%29%20decreased%20in%20the%20hippocampal%20region%20of%20the%20brain%20in%20comparison%20to%20the%20UCMS%20group.%20Overall%2C%20these%20results%20suggest%20that%20Vit%20C%20could%20reverse%20UCMS-induced%20learning%20and%20memory%20impairment%20possibly%20through%20the%20modulation%20of%20brain%20OS.Key%20points%20Memory%20and%20learning%20impairments%20were%20induced%20by%20unpredictable%20chronic%20mild%20stress%20%28UCMS%29Vitamin%20C%20could%20prevent%20cognitive%20impairments%20caused%20by%20UCMS%20in%20rats%20by%20attenuation%20of%20oxidative%20stress%20in%20the%20brain.%22%2C%22date%22%3A%222022-11-21%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1080%5C%2F1028415X.2022.2145423%22%2C%22ISSN%22%3A%221028-415X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F1028415X.2022.2145423%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-01-12T18%3A26%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22KVJVVSHA%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pullar%20et%20al.%22%2C%22parsedDate%22%3A%222018-07-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cb%3EHigh%20Vitamin%20C%20Status%20Is%20Associated%20with%20Elevated%20Mood%20in%20Male%20Tertiary%20Students%3C%5C%2Fb%3E%23%23%212018%20%7C%20Pullar%20JM%2C%20Carr%20AC%2C%20et%20al.%20%7C%20%3Ci%3EAntioxidants%20%28Basel%29%3C%5C%2Fi%3E.%202018%3B7%287%29%3A91.%20%23%23%21%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fantiox7070091%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fantiox7070091%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20Vitamin%20C%20Status%20Is%20Associated%20with%20Elevated%20Mood%20in%20Male%20Tertiary%20Students%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliet%20M.%22%2C%22lastName%22%3A%22Pullar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anitra%20C.%22%2C%22lastName%22%3A%22Carr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20M.%22%2C%22lastName%22%3A%22Bozonet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margreet%20C.%20M.%22%2C%22lastName%22%3A%22Vissers%22%7D%5D%2C%22abstractNote%22%3A%22Micronutrient%20status%20is%20thought%20to%20impact%20on%20psychological%20mood%20due%20to%20the%20role%20of%20nutrients%20in%20brain%20structure%20and%20function.%20The%20aim%20of%20the%20current%20study%20was%20to%20investigate%20the%20association%20of%20vitamin%20C%20status%20with%20mood%20state%20in%20a%20sample%20of%20male%20tertiary%20students.%20We%20measured%20fasting%20plasma%20vitamin%20C%20levels%20as%20an%20indicator%20of%20vitamin%20C%20status%2C%20and%20subjective%20mood%20was%20determined%20using%20the%20Profile%20of%20Mood%20States%20%28POMS%29%20questionnaire.%20One%20hundred%20and%20thirty-nine%20male%20students%20aged%2018%20to%2035%20years%20were%20recruited%20from%20local%20tertiary%20institutes%20in%20Christchurch%2C%20New%20Zealand.%20The%20average%20plasma%20vitamin%20C%20concentration%20was%2058.2%20%5Cu00b1%2018.6%20%28SD%29%20%5Cu00b5mol%5C%2FL%20and%20the%20average%20total%20mood%20disturbance%20score%20was%2025.5%20%5Cu00b1%2026.6%20%28possible%20score%20%5Cu221232%20to%20200%20measuring%20low%20to%20high%20mood%20disturbance%2C%20respectively%29.%20Plasma%20vitamin%20C%20concentration%20was%20inversely%20correlated%20with%20total%20mood%20disturbance%20as%20assessed%20by%20POMS%20%28r%20%3D%20%5Cu22120.181%2C%20p%20%3C%200.05%29.%20Examination%20of%20the%20individual%20POMS%20subscales%20also%20showed%20inverse%20associations%20of%20vitamin%20C%20status%20with%20depression%2C%20confusion%2C%20and%20anger.%20These%20findings%20suggest%20that%20high%20vitamin%20C%20status%20may%20be%20associated%20with%20improved%20overall%20mood%20in%20young%20adult%20males.%22%2C%22date%22%3A%222018-7-16%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fantiox7070091%22%2C%22ISSN%22%3A%222076-3921%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC6071228%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-01-12T18%3A26%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22WFL5SEHE%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22May%22%2C%22parsedDate%22%3A%222012%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cb%3EVitamin%20C%20transport%20and%20its%20role%20in%20the%20central%20nervous%20system%3C%5C%2Fb%3E%23%23%212012%20%7C%20May%20JM.%20%7C%20%3Ci%3ESubcell%20Biochem%3C%5C%2Fi%3E.%202012%3B56%3A85-103.%20%23%23%21%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2F978-94-007-2199-9_6%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2F978-94-007-2199-9_6%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vitamin%20C%20transport%20and%20its%20role%20in%20the%20central%20nervous%20system%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20M.%22%2C%22lastName%22%3A%22May%22%7D%5D%2C%22abstractNote%22%3A%22Vitamin%20C%2C%20or%20ascorbic%20acid%2C%20is%20important%20as%20an%20antioxidant%20and%20participates%20in%20numerous%20cellular%20functions.%20Although%20it%20circulates%20in%20plasma%20in%20micromolar%20concentrations%2C%20it%20reaches%20millimolar%20concentrations%20in%20most%20tissues.%20These%20high%20ascorbate%20cellular%20concentrations%20are%20thought%20to%20be%20generated%20and%20maintained%20by%20the%20SVCT2%20%28Slc23a2%29%2C%20a%20specific%20transporter%20for%20ascorbate.%20The%20vitamin%20is%20also%20readily%20recycled%20from%20its%20oxidized%20forms%20inside%20cells.%20Neurons%20in%20the%20central%20nervous%20system%20%28CNS%29%20contain%20some%20of%20the%20highest%20ascorbic%20acid%20concentrations%20of%20mammalian%20tissues.%20Intracellular%20ascorbate%20serves%20several%20functions%20in%20the%20CNS%2C%20including%20antioxidant%20protection%2C%20peptide%20amidation%2C%20myelin%20formation%2C%20synaptic%20potentiation%2C%20and%20protection%20against%20glutamate%20toxicity.%20The%20importance%20of%20the%20SVCT2%20for%20CNS%20function%20is%20supported%20by%20the%20finding%20that%20its%20targeted%20deletion%20in%20mice%20causes%20widespread%20cerebral%20hemorrhage%20and%20death%20on%20post-natal%20day%20one.%20Neuronal%20ascorbate%20content%20as%20maintained%20by%20this%20protein%20also%20has%20relevance%20for%20human%20disease%2C%20since%20ascorbate%20supplements%20decrease%20infarct%20size%20in%20ischemia-reperfusion%20injury%20models%20of%20stroke%2C%20and%20since%20ascorbate%20may%20protect%20neurons%20from%20the%20oxidant%20damage%20associated%20with%20neurodegenerative%20diseases%20such%20as%20Alzheimer%5Cu2019s%2C%20Parkinson%5Cu2019s%2C%20and%20Huntington%5Cu2019s.%20The%20aim%20of%20this%20review%20is%20to%20assess%20the%20role%20of%20the%20SVCT2%20in%20regulating%20neuronal%20ascorbate%20homeostasis%20and%20the%20extent%20to%20which%20ascorbate%20affects%20brain%20function%20and%20antioxidant%20defenses%20in%20the%20CNS.%22%2C%22date%22%3A%222012%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2F978-94-007-2199-9_6%22%2C%22ISSN%22%3A%220306-0225%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC3725125%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-01-12T21%3A56%3A59Z%22%7D%7D%5D%7D
Preventive impacts of vitamin C on memory damage caused by unpredictable chronic mild stress in relation to biochemical parameters in the hippocampus of male rats##!2022 | Moghimian M, Azin S, et al. | Nutritional Neuroscience. 2022;0(0):1-10. ##!http://doi.org/10.1080/1028415X.2022.2145423
High Vitamin C Status Is Associated with Elevated Mood in Male Tertiary Students##!2018 | Pullar JM, Carr AC, et al. | Antioxidants (Basel). 2018;7(7):91. ##!http://doi.org/10.3390/antiox7070091
Vitamin C transport and its role in the central nervous system##!2012 | May JM. | Subcell Biochem. 2012;56:85-103. ##!http://doi.org/10.1007/978-94-007-2199-9_6