10725819
1
american-medical-association
50
default
25
https://healthresearchreport.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A250%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22494VZCMS%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELutein%20and%20Zeaxanthin%20and%20Their%20Roles%20in%20Age-Related%20Macular%20Degeneration%26%23x2014%3BNeurodegenerative%20Disease%20-%20PMC.%20Accessed%20January%2022%2C%202024.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC8874683%5C%2F%27%3Ehttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC8874683%5C%2F%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Lutein%20and%20Zeaxanthin%20and%20Their%20Roles%20in%20Age-Related%20Macular%20Degeneration%5Cu2014Neurodegenerative%20Disease%20-%20PMC%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC8874683%5C%2F%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-01-22T13%3A48%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22CANYJ4XM%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cooper%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ECooper%20ID%2C%20Sanchez-Pizarro%20C%2C%20Norwitz%20NG%2C%20et%20al.%20Thyroid%20markers%20and%20body%20composition%20predict%20LDL-cholesterol%20change%20in%20lean%20healthy%20women%20on%20a%20ketogenic%20diet%3A%20experimental%20support%20for%20the%20lipid%20energy%20model.%20%3Ci%3EFrontiers%20in%20Endocrinology%3C%5C%2Fi%3E.%202023%3B14.%20Accessed%20December%2021%2C%202023.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffendo.2023.1326768%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffendo.2023.1326768%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Thyroid%20markers%20and%20body%20composition%20predict%20LDL-cholesterol%20change%20in%20lean%20healthy%20women%20on%20a%20ketogenic%20diet%3A%20experimental%20support%20for%20the%20lipid%20energy%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabella%20D.%22%2C%22lastName%22%3A%22Cooper%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudio%22%2C%22lastName%22%3A%22Sanchez-Pizarro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20G.%22%2C%22lastName%22%3A%22Norwitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Feldman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvoni%22%2C%22lastName%22%3A%22Kyriakidou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kurtis%22%2C%22lastName%22%3A%22Edwards%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucy%22%2C%22lastName%22%3A%22Petagine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bradley%20T.%22%2C%22lastName%22%3A%22Elliot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Soto-Mota%22%7D%5D%2C%22abstractNote%22%3A%22IntroductionThere%20is%20a%20large%20heterogeneity%20in%20LDL-cholesterol%20change%20among%20individuals%20adopting%20ketogenic%20diets.%20Interestingly%2C%20lean%20metabolically%20healthy%20individuals%20seem%20to%20be%20particularly%20susceptible%2C%20with%20an%20inverse%20association%20between%20body%20mass%20index%20and%20LDL-cholesterol%20change.%20The%20lipid%20energy%20model%20proposes%20that%2C%20in%20lean%20healthy%20individuals%2C%20carbohydrate%20restriction%20upregulates%20systemic%20lipid%20trafficking%20to%20meet%20energy%20demands.%20To%20test%20if%20anthropometric%20and%20energy%20metabolism%20markers%20predict%20LDL-cholesterol%20change%20during%20carbohydrate%20restriction.MethodsTen%20lean%2C%20healthy%2C%20premenopausal%20women%20who%20habitually%20consumed%20a%20ketogenic%20diet%20for%20%5Cu22656%20months%20were%20engaged%20in%20a%20three-phase%20crossover%20study%20consisting%20of%20continued%20nutritional%20ketosis%2C%20suppression%20of%20ketosis%20with%20carbohydrate%20reintroduction%2C%20and%20return%20to%20nutritional%20ketosis.%20Each%20phase%20lasted%2021%20days.%20The%20predictive%20performance%20of%20all%20available%20relevant%20variables%20was%20evaluated%20with%20the%20linear%20mixed-effects%20models.ResultsAll%20body%20composition%20metrics%2C%20free%20T3%20and%20total%20T4%2C%20were%20significantly%20associated%20with%20LDL-cholesterol%20change.%20In%20an%20interaction%20model%20with%20BMI%20and%20free%20T3%2C%20both%20markers%20were%20significant%20independent%20and%20interacting%20predictors%20of%20LDL-cholesterol%20change.%20Neither%20saturated%20fat%2C%20HOMA-IR%2C%20leptin%2C%20adiponectin%2C%20TSH%2C%20nor%20rT3%20was%20associated%20with%20LDL-cholesterol%20changes.DiscussionAmong%20lean%2C%20healthy%20women%20undergoing%20carbohydrate%20restriction%2C%20body%20composition%20and%20energy%20metabolism%20markers%20are%20major%20drivers%20of%20LDL-cholesterol%20change%2C%20not%20saturated%20fat%2C%20consistent%20with%20the%20lipid%20energy%20model.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221664-2392%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffendo.2023.1326768%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-12-21T13%3A15%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22EJZKMRKP%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hemil%5Cu00e4%20and%20Chalker%22%2C%22parsedDate%22%3A%222023-12-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHemil%26%23xE4%3B%20H%2C%20Chalker%20E.%20Vitamin%20C%20reduces%20the%20severity%20of%20common%20colds%3A%20a%20meta-analysis.%20%3Ci%3EBMC%20Public%20Health%3C%5C%2Fi%3E.%202023%3B23%281%29%3A2468.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-023-17229-8%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-023-17229-8%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vitamin%20C%20reduces%20the%20severity%20of%20common%20colds%3A%20a%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harri%22%2C%22lastName%22%3A%22Hemil%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Chalker%22%7D%5D%2C%22abstractNote%22%3A%22Randomized%20trials%20have%20shown%20that%20vitamin%20C%20shortens%20the%20duration%20of%20common%20colds.%20Some%20trials%20reported%20greater%20effects%20on%20severe%20cold%20symptoms%20compared%20with%20mild%20symptoms.%20This%20review%20systematically%20compares%20the%20effects%20of%20vitamin%20C%20on%20severe%20and%20mild%20common%20cold%20symptoms.%22%2C%22date%22%3A%222023-12-11%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12889-023-17229-8%22%2C%22ISSN%22%3A%221471-2458%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-023-17229-8%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-12-13T13%3A25%3A07Z%22%7D%7D%2C%7B%22key%22%3A%223SSFEG4P%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Norwitz%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ENorwitz%20NG%2C%20Mindrum%20MR%2C%20Giral%20P%2C%20et%20al.%20Elevated%20LDL-cholesterol%20levels%20among%20lean%20mass%20hyper-responders%20on%20low-carbohydrate%20ketogenic%20diets%20deserve%20urgent%20clinical%20attention%20and%20further%20research.%20%3Ci%3EJournal%20of%20Clinical%20Lipidology%3C%5C%2Fi%3E.%202022%3B16%286%29%3A765-768.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacl.2022.10.010%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacl.2022.10.010%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Elevated%20LDL-cholesterol%20levels%20among%20lean%20mass%20hyper-responders%20on%20low-carbohydrate%20ketogenic%20diets%20deserve%20urgent%20clinical%20attention%20and%20further%20research%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20G.%22%2C%22lastName%22%3A%22Norwitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20R.%22%2C%22lastName%22%3A%22Mindrum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Giral%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anatol%22%2C%22lastName%22%3A%22Kontush%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Soto-Mota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20R.%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominic%20P.%22%2C%22lastName%22%3A%22D%27Agostino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Venkat%20S.%22%2C%22lastName%22%3A%22Manubolu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Budoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%20M.%22%2C%22lastName%22%3A%22Krauss%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022-11-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jacl.2022.10.010%22%2C%22ISSN%22%3A%221933-2874%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1933287422002951%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-12-11T18%3A52%3A44Z%22%7D%7D%2C%7B%22key%22%3A%222DZTFUA6%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Soltani%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESoltani%20S%2C%20Jayedi%20A%2C%20Abdollahi%20S%2C%20Vasmehjani%20AA%2C%20Meshkini%20F%2C%20Shab-Bidar%20S.%20Effect%20of%20carbohydrate%20restriction%20on%20body%20weight%20in%20overweight%20and%20obese%20adults%3A%20a%20systematic%20review%20and%20dose%26%23x2013%3Bresponse%20meta-analysis%20of%20110%20randomized%20controlled%20trials.%20%3Ci%3EFrontiers%20in%20Nutrition%3C%5C%2Fi%3E.%202023%3B10.%20Accessed%20December%207%2C%202023.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1287987%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1287987%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20carbohydrate%20restriction%20on%20body%20weight%20in%20overweight%20and%20obese%20adults%3A%20a%20systematic%20review%20and%20dose%5Cu2013response%20meta-analysis%20of%20110%20randomized%20controlled%20trials%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sepideh%22%2C%22lastName%22%3A%22Soltani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmad%22%2C%22lastName%22%3A%22Jayedi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shima%22%2C%22lastName%22%3A%22Abdollahi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azam%20Ahmadi%22%2C%22lastName%22%3A%22Vasmehjani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatemeh%22%2C%22lastName%22%3A%22Meshkini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sakineh%22%2C%22lastName%22%3A%22Shab-Bidar%22%7D%5D%2C%22abstractNote%22%3A%22IntroductionCarbohydrate-restricted%20diets%20are%20one%20of%20the%20most%20effective%20dietary%20interventions%20for%20weight%20loss.%20However%2C%20the%20optimum%20carbohydrate%20intake%20for%20implementing%20the%20most%20effective%20weight-loss%20interventions%20is%20still%20being%20discussed.%20We%20aimed%20to%20determine%20the%20optimum%20carbohydrate%20intake%20for%20short-%20and%20long-term%20weight%20loss%20in%20adults%20with%20overweight%20and%20obesity.MethodsWe%20searched%20PubMed%2C%20Scopus%2C%20Web%20of%20Science%2C%20and%20CENTRAL%20from%20inception%20to%20May%202021%20for%20randomized%20controlled%20trials%20examining%20the%20effect%20of%20a%20carbohydrate-restricted%20diet%20%28%5Cu226445%25%20of%20energy%20intake%29%20as%20compared%20to%20a%20control%20diet%20%28carbohydrate%20intake%20%3E45%25%20of%20energy%20intake%29%20on%20body%20weight%20in%20adults%20with%20overweight%5C%2Fobesity.%20A%20random-effects%20dose%5Cu2013response%20meta-analysis%20was%20conducted%20to%20calculate%20the%20mean%20difference%20for%20each%2010%25%20decrease%20in%20carbohydrate%20intake%20at%20the%206-month%20follow-up%20%281%20to%206%5Cu2009months%29%2C%2012-month%20follow-up%20%286%20to%2012%5Cu2009months%29%2C%20and%20follow-up%20longer%20than%2012%5Cu2009months.%20The%20shape%20of%20the%20dose-dependent%20effects%20was%20also%20evaluated.%20The%20certainty%20of%20the%20evidence%20was%20rated%20using%20the%20GRADE%20approach.%20The%20minimal%20clinically%20important%20difference%20%28MCID%29%20threshold%20was%20defined%20as%205%25%20weight%20loss%20%28equal%20to%204.39%5Cu2009kg%29.ResultsA%20total%20of%20110%20trials%20were%20selected%20for%20the%20present%20meta-analysis.%20In%20the%20linear%20dose%5Cu2013response%20meta-analysis%2C%20each%2010%25%20decrease%20in%20carbohydrate%20intake%20reduced%20body%20weight%20by%200.64%5Cu2009kg%20%2895%25%20CI%3A%20%5Cu22120.79%20to%20%5Cu22120.49%3B%20n%5Cu2009%3D%5Cu2009101%20trials%20with%204%2C135%20participants%2C%20high-certainty%20evidence%29%20at%20the%206-month%20follow-up%20and%20by%201.15%5Cu2009kg%20%2895%25%20CI%3A%20%5Cu22121.61%20to%20%5Cu22120.69%3B%2042%20trials%20with%202%2C657%20participants%2C%20moderate-certainty%20evidence%29%20at%20the%2012-month%20follow-up.%20Non-linear%20dose%5Cu2013response%20meta-analyses%20indicated%20a%20monotonic%20reduction%20in%20body%20weight%20with%20the%20decrease%20in%20carbohydrate%20intake%2C%20with%20the%20greatest%20reduction%20at%205%25%20at%20the%206-month%20follow-up%20%28mean%20difference%205%25%3A%20%5Cu22123.96%5Cu2009kg%2C%2095%25%20CI%3A%20%5Cu22124.92%20to%20%5Cu22123.00%29%20and%2010%25%20at%20the%2012-month%20follow-up%20%28mean%20difference%2010%25%3A%20%5Cu22126.26%5Cu2009kg%2C%2095%25%20CI%3A%20%5Cu221210.42%20to%20%5Cu22122.10%29.%20At%20follow-up%20longer%20than%2012%5Cu2009months%2C%20dose%5Cu2013response%20analyses%20suggested%20a%20non-linear%20effect%2C%20wherein%20carbohydrate%20intakes%20higher%20than%2040%25%20and%20lower%20than%2030%25%20were%20not%20effective%20for%20weight%20loss.DiscussionCarbohydrate%20restriction%20is%20an%20effective%20dietary%20strategy%20for%20important%20weight%20loss%20in%20adults%20with%20overweight%20and%20obesity.%20At%206-month%20and%2012-month%20follow-ups%2C%20body%20weight%20decreased%20proportionally%2C%20more%20than%20the%20MCID%20threshold%2C%20along%20with%20the%20decrease%20in%20carbohydrate%20intake.%20At%20follow-up%20longer%20than%2012%20months%2C%20there%20was%20a%20non-linear%20effect%2C%20with%20the%20greatest%20reduction%20at%2030%25%20carbohydrate%20intake.Systematic%20review%20registrationhttps%3A%5C%2F%5C%2Fwww.crd.york.ac.uk%5C%2Fprospero%5C%2F%2C%20identifier%20CRD42022315042.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222296-861X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1287987%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-12-07T01%3A32%3A07Z%22%7D%7D%2C%7B%22key%22%3A%225TUMNL5X%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rouleau%20et%20al.%22%2C%22parsedDate%22%3A%222016-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ERouleau%20L%2C%20Antony%20AN%2C%20Bisetto%20S%2C%20et%20al.%20Synergistic%20effects%20of%20ascorbate%20and%20sorafenib%20in%20hepatocellular%20carcinoma%3A%20New%20insights%20into%20ascorbate%20cytotoxicity.%20%3Ci%3EFree%20Radic%20Biol%20Med%3C%5C%2Fi%3E.%202016%3B95%3A308-322.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.freeradbiomed.2016.03.031%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.freeradbiomed.2016.03.031%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Synergistic%20effects%20of%20ascorbate%20and%20sorafenib%20in%20hepatocellular%20carcinoma%3A%20New%20insights%20into%20ascorbate%20cytotoxicity%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauren%22%2C%22lastName%22%3A%22Rouleau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anil%20Noronha%22%2C%22lastName%22%3A%22Antony%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Bisetto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Newberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cataldo%22%2C%22lastName%22%3A%22Doria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Levine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20A.%22%2C%22lastName%22%3A%22Monti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20B.%22%2C%22lastName%22%3A%22Hoek%22%7D%5D%2C%22abstractNote%22%3A%22We%20investigated%20the%20mechanism%20of%20selective%20ascorbate-induced%20cytotoxicity%20in%20tumor%20cells%2C%20including%20Hep%20G2%20cells%2C%20compared%20to%20primary%20hepatocytes.%20H2O2%20formation%20was%20required%20for%20ascorbate%20cytotoxicity%2C%20as%20extracellular%20catalase%20treatment%20protected%20tumor%20cells.%20H2O2%20generated%20by%20glucose%20oxidase%20treatment%20also%20caused%20cell%20killing%2C%20but%20treatment%20with%20a%20pharmacological%20dose%20%285-20%20mM%29%20of%20ascorbate%20was%20significantly%20more%20cytotoxic%20at%20comparable%20rates%20of%20H2O2%20production%2C%20suggesting%20that%20ascorbate%20enhanced%20H2O2%20cytotoxicity.%20This%20was%20further%20supported%20by%20the%20finding%20that%20ascorbate%20at%20a%20non-cytotoxic%20dose%20%281%20mM%29%20enhanced%20cell%20killing%20caused%20by%20glucose%20oxidase.%20Consistent%20with%20this%20conclusion%2C%20ascorbate%20treatment%20caused%20deregulation%20of%20cellular%20calcium%20homeostasis%2C%20resulting%20in%20massive%20mitochondrial%20calcium%20accumulation.%20Ascorbate%20acted%20synergistically%20with%20the%20chemotherapeutic%20sorafenib%20in%20killing%20Hep%20G2%20cells%2C%20but%20not%20primary%20hepatocytes%2C%20suggesting%20adjuvant%20ascorbate%20treatment%20can%20broaden%20sorafenib%27s%20therapeutic%20range.%20Sorafenib%20caused%20mitochondrial%20depolarization%20and%20prevented%20mitochondrial%20calcium%20sequestration.%20Subsequent%20ascorbate%20addition%20further%20deregulated%20cellular%20calcium%20homeostasis%20promoting%20cell%20death.%20Additionally%2C%20we%20present%20the%20case%20of%20a%20patient%20with%20hepatocellular%20carcinoma%20%28HCC%29%20who%20had%20prolonged%20regression%20of%20a%20rib%20metastasis%20upon%20combination%20treatment%20with%20ascorbate%20and%20sorafenib%2C%20indicating%20that%20these%20studies%20have%20direct%20clinical%20relevance.%22%2C%22date%22%3A%222016-6%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.freeradbiomed.2016.03.031%22%2C%22ISSN%22%3A%220891-5849%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC4867251%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-04T20%3A56%3A12Z%22%7D%7D%2C%7B%22key%22%3A%2234BDCMTU%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gomez-Cabrera%20et%20al.%22%2C%22parsedDate%22%3A%222008-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EGomez-Cabrera%20MC%2C%20Domenech%20E%2C%20Romagnoli%20M%2C%20et%20al.%20Oral%20administration%20of%20vitamin%20C%20decreases%20muscle%20mitochondrial%20biogenesis%20and%20hampers%20training-induced%20adaptations%20in%20endurance%20performance.%20%3Ci%3EThe%20American%20Journal%20of%20Clinical%20Nutrition%3C%5C%2Fi%3E.%202008%3B87%281%29%3A142-149.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fajcn%5C%2F87.1.142%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fajcn%5C%2F87.1.142%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Oral%20administration%20of%20vitamin%20C%20decreases%20muscle%20mitochondrial%20biogenesis%20and%20hampers%20training-induced%20adaptations%20in%20endurance%20performance%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mari-Carmen%22%2C%22lastName%22%3A%22Gomez-Cabrera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Domenech%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Romagnoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alessandro%22%2C%22lastName%22%3A%22Arduini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Consuelo%22%2C%22lastName%22%3A%22Borras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Federico%20V%22%2C%22lastName%22%3A%22Pallardo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%22%2C%22lastName%22%3A%22Sastre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%22%2C%22lastName%22%3A%22Vi%5Cu00f1a%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnExercise%20practitioners%20often%20take%20vitamin%20C%20supplements%20because%20intense%20muscular%20contractile%20activity%20can%20result%20in%20oxidative%20stress%2C%20as%20indicated%20by%20altered%20muscle%20and%20blood%20glutathione%20concentrations%20and%20increases%20in%20protein%2C%20DNA%2C%20and%20lipid%20peroxidation.%20There%20is%2C%20however%2C%20considerable%20debate%20regarding%20the%20beneficial%20health%20effects%20of%20vitamin%20C%20supplementation.%5CnObjective%5CnThis%20study%20was%20designed%20to%20study%20the%20effect%20of%20vitamin%20C%20on%20training%20efficiency%20in%20rats%20and%20in%20humans.%5CnDesign%5CnThe%20human%20study%20was%20double-blind%20and%20randomized.%20Fourteen%20men%20%2827%5Cu201336%20y%20old%29%20were%20trained%20for%208%20wk.%20Five%20of%20the%20men%20were%20supplemented%20daily%20with%20an%20oral%20dose%20of%201%20g%20vitamin%20C.%20In%20the%20animal%20study%2C%2024%20male%20Wistar%20rats%20were%20exercised%20under%202%20different%20protocols%20for%203%20and%206%20wk.%20Twelve%20of%20the%20rats%20were%20treated%20with%20a%20daily%20dose%20of%20vitamin%20C%20%280.24%20mg%5C%2Fcm2%20body%20surface%20area%29.%5CnResults%5CnThe%20administration%20of%20vitamin%20C%20significantly%20%28P%20%3D%200.014%29%20hampered%20endurance%20capacity.%20The%20adverse%20effects%20of%20vitamin%20C%20may%20result%20from%20its%20capacity%20to%20reduce%20the%20exercise-induced%20expression%20of%20key%20transcription%20factors%20involved%20in%20mitochondrial%20biogenesis.%20These%20factors%20are%20peroxisome%20proliferator%5Cu2013activated%20receptor%20co-activator%201%2C%20nuclear%20respiratory%20factor%201%2C%20and%20mitochondrial%20transcription%20factor%20A.%20Vitamin%20C%20also%20prevented%20the%20exercise-induced%20expression%20of%20cytochrome%20C%20%28a%20marker%20of%20mitochondrial%20content%29%20and%20of%20the%20antioxidant%20enzymes%20superoxide%20dismutase%20and%20glutathione%20peroxidase.%5CnConclusion%5CnVitamin%20C%20supplementation%20decreases%20training%20efficiency%20because%20it%20prevents%20some%20cellular%20adaptations%20to%20exercise.%22%2C%22date%22%3A%222008-01-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fajcn%5C%2F87.1.142%22%2C%22ISSN%22%3A%220002-9165%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0002916523234474%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-04T20%3A26%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22SI875SDH%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EVitamin%20C%20and%20Colds.%20WebMD.%20Accessed%20December%206%2C%202022.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.webmd.com%5C%2Fcold-and-flu%5C%2Fcold-guide%5C%2Fvitamin-c-for-common-cold%27%3Ehttps%3A%5C%2F%5C%2Fwww.webmd.com%5C%2Fcold-and-flu%5C%2Fcold-guide%5C%2Fvitamin-c-for-common-cold%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Vitamin%20C%20and%20Colds%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22WebMD%20explains%20the%20role%20vitamin%20C%20plays%20in%20preventing%20and%20treating%20the%20common%20cold.%22%2C%22date%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webmd.com%5C%2Fcold-and-flu%5C%2Fcold-guide%5C%2Fvitamin-c-for-common-cold%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-04T19%3A18%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22UERP3FQX%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zarakowska%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-29%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EZarakowska%20E%2C%20Guz%20J%2C%20Mijewski%20P%2C%20et%20al.%20Intracellular%20ascorbate%20is%20a%20safe-guard%20and%5C%2For%20reservoir%20for%20plasma%20vitamin%20C%20in%20prostate%20cancer%20patients%20undergoing%20radiotherapy.%20%3Ci%3EFree%20Radical%20Biology%20and%20Medicine%3C%5C%2Fi%3E.%20Published%20online%20November%2029%2C%202023.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.freeradbiomed.2023.11.024%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.freeradbiomed.2023.11.024%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intracellular%20ascorbate%20is%20a%20safe-guard%20and%5C%2For%20reservoir%20for%20plasma%20vitamin%20C%20in%20prostate%20cancer%20patients%20undergoing%20radiotherapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ewelina%22%2C%22lastName%22%3A%22Zarakowska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jolanta%22%2C%22lastName%22%3A%22Guz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pawel%22%2C%22lastName%22%3A%22Mijewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aleksandra%22%2C%22lastName%22%3A%22Wasilow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakub%22%2C%22lastName%22%3A%22Wozniak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krzysztof%22%2C%22lastName%22%3A%22Roszkowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marek%22%2C%22lastName%22%3A%22Foksinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Gackowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryszard%22%2C%22lastName%22%3A%22Olinski%22%7D%5D%2C%22abstractNote%22%3A%22Prostate%20cancer%20%28PC%29%20represents%20one%20of%20the%20most%20common%20cancer%20types%20worldwide%20and%20many%20patients%20suffering%20from%20this%20kind%20of%20cancer%20are%20treated%20with%20radiotherapy%20%28RTH%29.%20Ionizing%20irradiation%20is%20closely%20associated%20with%20reactive%20oxygen%20species%20%28ROS%29%20production%20and%20oxidative%20stress.%20Over%20the%20years%20the%20role%20of%20vitamin%20C%20%28VC%29%20in%20cancer%20prevention%20has%20been%20highlighted%20as%20it%20may%20be%20mediated%20by%20its%20ability%20to%20neutralize%20pro-carcinogenic%20ROS.%20However%2C%20the%20debate%20concerning%20the%20presence%20of%20VC%20in%20blood%20and%20its%20beneficial%20effect%20on%20the%20survival%20of%20cancer%20patients%20is%20inconsistent%20and%20controversial.%20To%20our%20best%20knowledge%20until%20recently%20there%20have%20been%20no%20studies%20concerning%20such%20a%20role%20of%20intracellular%20VC%20%28iVC%29.%20In%20the%20present%20study%2C%20blood%20and%20intracellular%20concentrations%20of%20vitamin%20C%20were%20analyzed%20along%20with%20the%20level%20of%208-oxo-7%2C8-dihydro-2%5Cu2032-deoxyguanosine%20%288-oxodG%29%2C%20as%20an%20established%20marker%20of%20the%20stress%20condition%2C%20in%20leukocytes%20of%20PC%20patients%20during%20the%20course%20of%20radiotherapy.%20The%20level%20of%20intracellular%20vitamin%20C%20significantly%20decreased%20in%20PC%20patients%20in%20comparison%20with%20the%20healthy%20group%2C%20while%20there%20was%20no%20differences%20in%20blood%20VC.%20It%20was%20observed%20that%20a%20sub-group%20of%20the%20PC%20patients%20reacted%20to%20RTH%20decreasing%20VC%20in%20leukocytes%20%28group%20A%29%2C%20while%20the%20other%20sub-group%20acted%20the%20other%20way%20round%2C%20significantly%20increasing%20its%20level%20%28group%20B%29.%20Under%20stressful%20conditions%20%28RTH%29%20leukocytes%20react%20in%20two%20different%20ways.%20Both%20ways%20are%20in%20good%20agreement%20with%20two%20well%20recognised%20functions%2C%20proposed%20for%20iVC%3B%20it%20may%20serve%20as%20a%20save%20factor%2C%20to%20protect%20the%20cellular%20DNA%2C%20increasing%20its%20concentration%20inside%20the%20cell%20%28group%20B%29%2C%20and%20as%20a%20reservoir%20decreasing%20the%20VC%20level%20inside%20leukocytes%20and%20releasing%20VC%20into%20the%20plasma%20to%20rescue%20its%20physiological%20level%20%28group%20A%29.%20It%20was%20also%20demonstrated%20that%20there%20was%20a%20relationship%20between%20the%20level%20of%208-oxodG%20in%20leukocytes%27%20DNA%20and%20the%20markers%20of%20RTH%20toxicity.%22%2C%22date%22%3A%222023-11-29%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.freeradbiomed.2023.11.024%22%2C%22ISSN%22%3A%220891-5849%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0891584923011255%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-03T22%3A50%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22WQBGEIBD%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhao%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EZhao%20X%2C%20Liu%20M%2C%20Li%20C%2C%20et%20al.%20High%20dose%20Vitamin%20C%20inhibits%20PD-L1%20by%20ROS-pSTAT3%20signal%20pathway%20and%20enhances%20T%20cell%20function%20in%20TNBC.%20%3Ci%3EInt%20Immunopharmacol%3C%5C%2Fi%3E.%202023%3B126%3A111321.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.intimp.2023.111321%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.intimp.2023.111321%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20dose%20Vitamin%20C%20inhibits%20PD-L1%20by%20ROS-pSTAT3%20signal%20pathway%20and%20enhances%20T%20cell%20function%20in%20TNBC%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xixi%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mengjie%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chaofan%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoxiao%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiaqi%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongbing%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuqun%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jingkun%22%2C%22lastName%22%3A%22Qu%22%7D%5D%2C%22abstractNote%22%3A%22Vitamin%20C%20%28VitC%29%20presents%20excellent%20anti-tumor%20effect%20for%20long%20time.%20Recently%2C%20high%20dose%20VitC%20achieved%20by%20intravenous%20administration%20manifests%20superior%20anti-tumor%20effect.%20However%2C%20the%20functions%20and%20detailed%20mechanisms%20of%20high%20dose%20VitC%27s%20role%20in%20cancer%20immunity%20are%20not%20fully%20understood.%20This%20study%20investigates%20the%20effect%20of%20high%20dose%20VitC%20on%20PD-L1%20expression%20in%20triple%20negative%20breast%20cancer%20%28TNBC%29%20and%20the%20potential%20mechanism.%20Results%20showed%20VitC%20inhibited%20PD-L1%20expression%20in%20breast%20cancer%20cell%20lines%20and%20enhanced%20anti-tumor%20effects%20of%20T%20cells.%20Furthermore%2C%20we%20found%20VitC%20inhibited%20PD-L1%20transcription%20through%20ROS-pSTAT3%20signal%20pathways.%20Consistent%20with%20in%20vitro%20results%2C%20in%20vivo%20study%20showed%20VitC%20suppressed%20tumor%20growth%20in%20immunocompetent%20mice%20and%20enhanced%20CD8%2B%20T%20cells%20infiltration%20and%20function%20in%20tumor%20microenvironment.%20Our%20findings%20identify%20the%20effects%20of%20high%20dose%20VitC%20on%20PD-L1%20expression%20and%20provide%20a%20rationale%20for%20the%20use%20of%20high%20dose%20VitC%20as%20immunomodulator%20for%20cancer%20therapy.%22%2C%22date%22%3A%222023-12-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.intimp.2023.111321%22%2C%22ISSN%22%3A%221878-1705%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-03T22%3A48%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22A3J3MVAS%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22parsedDate%22%3A%222023-11-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EIntravenous%20Vitamin%20C%20Supplementation%20in%20Allogeneic%20Hematopoietic%20Cell%20Transplant%20Recipients%3A%20Salutary%20Impact%20on%20Clinical%20Outcomes.%20doi%3A10.21203%5C%2Frs.3.rs-3538792%5C%2Fv1%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Intravenous%20Vitamin%20C%20Supplementation%20in%20Allogeneic%20Hematopoietic%20Cell%20Transplant%20Recipients%3A%20Salutary%20Impact%20on%20Clinical%20Outcomes%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22Intravenous%20%28IV%29%20vitamin%20C%20improves%20organ%20function%20and%20reduces%20inflammation%20in%20sepsis%2C%20an%20inflammatory%20state%20like%20the%20post-hematopoietic%20stem%20cell%20transplant%20%28HCT%29%20milieu.%20The%20safety%20and%20efficacy%20of%20parenteral%20vitamin%20C%20after%20allogeneic%20HCT%20were%20evaluated%20in%20a%20phase%20I%5C%2FII%20trial.%20Clinical%20outcom...%22%2C%22date%22%3A%222023-11-10%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.researchsquare.com%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-02T17%3A50%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22XWWDBWWM%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Toor%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EToor%20A%2C%20Simmons%20G%2C%20Sabo%20R%2C%20et%20al.%20Intravenous%20Vitamin%20C%20Supplementation%20in%20Allogeneic%20Hematopoietic%20Cell%20Transplant%20Recipients%3A%20Salutary%20Impact%20on%20Clinical%20Outcomes.%20%3Ci%3ERes%20Sq%3C%5C%2Fi%3E.%20Published%20online%20November%2010%2C%202023%3Ars.3.rs-3538792.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21203%5C%2Frs.3.rs-3538792%5C%2Fv1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21203%5C%2Frs.3.rs-3538792%5C%2Fv1%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intravenous%20Vitamin%20C%20Supplementation%20in%20Allogeneic%20Hematopoietic%20Cell%20Transplant%20Recipients%3A%20Salutary%20Impact%20on%20Clinical%20Outcomes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amir%22%2C%22lastName%22%3A%22Toor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Simmons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roy%22%2C%22lastName%22%3A%22Sabo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22May%22%2C%22lastName%22%3A%22Aziz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robyn%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manjari%22%2C%22lastName%22%3A%22Sripa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cody%22%2C%22lastName%22%3A%22McIntire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Kreiger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donald%22%2C%22lastName%22%3A%22Brophy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramesh%22%2C%22lastName%22%3A%22Natarajan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alpha%22%2C%22lastName%22%3A%22Fowler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Roberts%22%7D%5D%2C%22abstractNote%22%3A%22Intravenous%20%28IV%29%20vitamin%20C%20improves%20organ%20function%20and%20reduces%20inflammation%20in%20sepsis%2C%20an%20inflammatory%20state%20like%20the%20post-hematopoietic%20stem%20cell%20transplant%20%28HCT%29%20milieu.%20The%20safety%20and%20efficacy%20of%20parenteral%20vitamin%20C%20after%20allogeneic%20HCT%20were%20evaluated%20in%20a%20phase%20I%5C%2FII%20trial.%20Clinical%20outcomes%20were%20compared%20with%20a%20propensity%20score%20-%20matched%20historical%20control.%5CnMethods%3A%5CnPatients%20with%20advanced%20hematologic%20malignancies%20received%20IV%20vitamin%20C%2C%2050mg%5C%2Fkg%5C%2Fd%2C%20divided%20into%203%20doses%20given%20on%20days%201-14%20after%20HCT%2C%20followed%20by%20500%20mg%20bid%20oral%20from%20day%2015%20until%206%20months%20post-SCT.%5CnResults%5Cn55%20patients%20received%20IV%20vitamin%20C.%20All%20patients%20were%20deficient%20in%20vitamin%20C%20at%20day%200.%20Vitamin%20C%20recipients%20had%20lower%20non-relapse%20mortality%20%28NRM%29%20%28p%20%3D%200.07%29%20and%20improved%20survival%20compared%20to%20historical%20controls%20%28p%3D0.06%29%2C%20with%20no%20attributable%20grade%203%20and%204%20toxicities.%20Vitamin%20C%20recipients%20had%20similar%20relapse%20rate%20and%20acute%20graft%20versus%20host%20disease%20%28GVHD%29%20%28p%3D0.35%29%2C%20but%20lower%20severe%20chronic%20GVHD%20%28p%3D0.35%29.%20Patients%20with%20myeloid%20malignancies%20had%20improved%20survival%20%28p%3D0.02%29%20and%20NRM%20%28p%3D0.009%29%2C%20as%20well%20as%20chronic%20GVHD%2C%20with%20similar%20relapse%20rates%20compared%20to%20controls.%5CnConclusions%3A%5CnIn%20patients%20undergoing%20allogeneic%20HCT%20the%20administration%20of%20IV%20vitamin%20C%20is%20safe%20and%20reduces%20non-relapse%20mortality%20and%20chronic%20GVHD%20improving%20overall%20survival.%22%2C%22date%22%3A%222023-11-10%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.21203%5C%2Frs.3.rs-3538792%5C%2Fv1%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10659544%5C%2F%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-12-02T17%3A48%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22LJQWHZG2%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lykkesfeldt%20and%20Carr%22%2C%22parsedDate%22%3A%222023-11-21%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELykkesfeldt%20J%2C%20Carr%20AC.%20Vitamin%20C1.%20%3Ci%3EAdvances%20in%20Nutrition%3C%5C%2Fi%3E.%20Published%20online%20November%2021%2C%202023%3A100155.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.advnut.2023.100155%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.advnut.2023.100155%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vitamin%20C1%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%22%2C%22lastName%22%3A%22Lykkesfeldt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anitra%20C.%22%2C%22lastName%22%3A%22Carr%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-11-21%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.advnut.2023.100155%22%2C%22ISSN%22%3A%222161-8313%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS2161831323014400%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-02T17%3A46%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22UELZUNAV%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Beglaryan%20et%20al.%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EBeglaryan%20N%2C%20Hakobyan%20G%2C%20Nazaretyan%20E.%20Vitamin%20C%20supplementation%20alleviates%20hypercortisolemia%20caused%20by%20chronic%20stress.%20%3Ci%3EStress%20and%20Health%3C%5C%2Fi%3E.%20n%5C%2Fa%28n%5C%2Fa%29.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fsmi.3347%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fsmi.3347%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vitamin%20C%20supplementation%20alleviates%20hypercortisolemia%20caused%20by%20chronic%20stress%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Narine%22%2C%22lastName%22%3A%22Beglaryan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gagik%22%2C%22lastName%22%3A%22Hakobyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduard%22%2C%22lastName%22%3A%22Nazaretyan%22%7D%5D%2C%22abstractNote%22%3A%22The%20aim%20of%20this%20study%20was%20to%20determine%20whether%20ascorbic%20acid%20%28AA%29%20supplementation%20can%20lower%20plasma%20levels%20of%20Cortisol%20and%20dehydroepiandrosterone-sulphate%20%28DHEA-S%29%20in%20patients%20diagnosed%20with%20functional%20hypercortisolemia%20due%20to%20unspecified%20chronic%20stress.%20Study%20includes%20data%20from%2069%20female%20with%20elevations%20in%20the%20cortisol%20and%20DHEA-S%20levels.%20Duration%20of%20follow-up%20was%202%20months.%20Patients%20were%20divided%20into%203%20groups.%20Group%20I%20included%20patients%2023%20with%20elevated%20cortisol%2C%20Group%20II%5Cu2014patients%2024%20with%20elevated%20levels%20of%20both%20hormones%2C%20Group%20III-%20patients%2022%20with%20normal%20cortisol%20and%20increased%20DHEA-S.%20Each%20group%20was%20randomly%20divided%20into%20two%20subgroups.%20The%20first%20subgroup%20was%20prescribed%201000%20mg%20daily%20oral%20dose%20of%20AA.%20The%20diet%20of%20the%20second%20subgroup%20were%20left%20unaltered.%20All%20patients%20have%20their%20hormones%20levels%20re-examined%202%20months%20later.%20After%202%20months%20of%20AA%20supplementation%20the%20mean%20levels%20of%20elevated%20plasma%20cortisol%20and%20DHEA-S%20decreased.%20In%20Group%20I%20the%20level%20of%20cortisol%20fell%20from%20780%20%5Cu00b1%2057%5Cu2013446%20%5Cu00b1%2026%20nmol%5C%2FL%2C%20p%20%3D%200.000065%20in%20Group%20II%20from%20657%20%5Cu00b1%2047%5Cu2013515%20%5Cu00b1%2029%20nmol%5C%2FL%2C%20p%20%3D%200.005.%20The%20elevated%20levels%20of%20DHEA-S%20have%20also%20declined%20in%20patients%20from%20AA-treated%20subgroups%20%28from%2013.9%20%5Cu00b1%201.6%5Cu20139.9%20%5Cu00b1%201.2%2C%20p%20%3D%200.0007%20in%20Group%20II%2C%20and%20from%2012.8%20%5Cu00b1%201.0%5Cu20137.8%20%5Cu00b1%201.4%2C%20p%20%3D%200.003%20in%20Group%20III%29.%20In%20untreated%20subgroups%20changes%20in%20hormone%20levels%20were%20insignificant.%20The%20study%20shows%20that%20female%20patients%20with%20functional%20hypercortisolemia%20or%20elevated%20levels%20of%20DHEA-S%20can%20be%20treated%20with%20AA%20to%20bring%20level%20of%20these%20hormones%20closer%20to%20a%20normal%20range.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fsmi.3347%22%2C%22ISSN%22%3A%221532-2998%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fsmi.3347%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-12-02T17%3A42%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22RN73TQB4%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Moreno-Macias%20and%20Romieu%22%2C%22parsedDate%22%3A%222014-05-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMoreno-Macias%20H%2C%20Romieu%20I.%20Effects%20of%20antioxidant%20supplements%20and%20nutrients%20on%20patients%20with%20asthma%20and%20allergies.%20%3Ci%3EJournal%20of%20Allergy%20and%20Clinical%20Immunology%3C%5C%2Fi%3E.%202014%3B133%285%29%3A1237-1244.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jaci.2014.03.020%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jaci.2014.03.020%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effects%20of%20antioxidant%20supplements%20and%20nutrients%20on%20patients%20with%20asthma%20and%20allergies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hortensia%22%2C%22lastName%22%3A%22Moreno-Macias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Romieu%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222014-05-01%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jaci.2014.03.020%22%2C%22ISSN%22%3A%220091-6749%2C%201097-6825%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.jacionline.org%5C%2Farticle%5C%2FS0091-6749%2814%2900442-4%5C%2Ffulltext%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-07T21%3A42%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22AQPAEUFI%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ram%5Cu00f3n%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-25%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ERam%26%23xF3%3Bn%20R%2C%20Holgu%26%23xED%3Bn%20E%2C%20Chiriboga%20JD%2C%20Rubio%20N%2C%20Ballesteros%20C%2C%20Ezechieli%20M.%20Anti-Inflammatory%20Effect%20of%20Vitamin%20C%20during%20the%20Postoperative%20Period%20in%20Patients%20Subjected%20to%20Total%20Knee%20Arthroplasty%3A%20A%20Randomized%20Controlled%20Trial.%20%3Ci%3EJ%20Pers%20Med%3C%5C%2Fi%3E.%202023%3B13%289%29%3A1299.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjpm13091299%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjpm13091299%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Anti-Inflammatory%20Effect%20of%20Vitamin%20C%20during%20the%20Postoperative%20Period%20in%20Patients%20Subjected%20to%20Total%20Knee%20Arthroplasty%3A%20A%20Randomized%20Controlled%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ricardo%22%2C%22lastName%22%3A%22Ram%5Cu00f3n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esteban%22%2C%22lastName%22%3A%22Holgu%5Cu00edn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20Daniel%22%2C%22lastName%22%3A%22Chiriboga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Newton%22%2C%22lastName%22%3A%22Rubio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlos%22%2C%22lastName%22%3A%22Ballesteros%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Ezechieli%22%7D%5D%2C%22abstractNote%22%3A%22Vitamin%20C%2C%20a%20potent%20reducing%20and%20antioxidant%20agent%2C%20plays%20an%20important%20role%20in%20the%20body%2C%20aiding%20in%20the%20growth%20of%20cartilage%20and%20bones.%20It%20is%20also%20involved%20in%20mechanisms%20that%20help%20reduce%20inflammation%20and%20its%20effects%20on%20the%20body.%20In%20addition%2C%20vitamin%20C%20decreases%20pro-inflammatory%20cytokines%2C%20such%20as%20IL-6%2C%20which%20produce%20acute-phase%20proteins%20such%20as%20CRP%20and%20influence%20inflammatory%20markers%20such%20as%20ESR.%20We%20carried%20out%20a%20study%20with%20110%20patients%20who%20underwent%20total%20knee%20replacement%20surgery.%20We%20divided%20the%20patients%20into%20two%20groups%2C%20in%20which%20the%20intervention%20group%20received%2015%20g%20of%20parenteral%20vitamin%20C%20during%20the%20immediate%20postoperative%20period%20while%20the%20control%20group%20did%20not.%20Patients%20who%20received%2015%20g%20of%20vitamin%20C%20after%20total%20knee%20replacement%20surgery%20had%20decreased%20inflammatory%20markers%2C%20specifically%20CRP%20and%20ESR.%20Overall%2C%20administering%20vitamin%20C%20in%20the%20post-surgical%20period%20results%20in%20improved%20management%20of%20inflammation%2C%20as%20evidenced%20by%20a%20decrease%20in%20CRP%20and%20ESR%20values.%20This%20leads%20to%20faster%20recovery%20and%20better%20healing%20outcomes%20for%20patients%20undergoing%20total%20knee%20replacement%20surgery.%20Furthermore%2C%20the%20beneficial%20effects%20of%20vitamin%20C%20in%20reducing%20proinflammatory%20cytokines%2C%20reducing%20the%20need%20for%20opioid%20analgesics%2C%20and%20its%20mild%20adverse%20effects%20make%20it%20a%20promising%20adjuvant%20in%20managing%20postoperative%20recovery.%22%2C%22date%22%3A%222023-8-25%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fjpm13091299%22%2C%22ISSN%22%3A%222075-4426%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10532858%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-01T13%3A38%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22RJ68IH6C%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Knorr%20et%20al.%22%2C%22parsedDate%22%3A%222023-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKnorr%20AL%2C%20Wexler%20RS%2C%20Fuller%20L.%20Treatment%20of%20Epstein-Barr%20Induced%20Hepatitis%20with%20High%20Dose%20Intravenous%20Vitamin%20C%3A%20A%20Case%20Report.%20%3Ci%3EIntegr%20Med%20%28Encinitas%29%3C%5C%2Fi%3E.%202023%3B22%284%29%3A24-27.%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Treatment%20of%20Epstein-Barr%20Induced%20Hepatitis%20with%20High%20Dose%20Intravenous%20Vitamin%20C%3A%20A%20Case%20Report%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adriane%20L.%22%2C%22lastName%22%3A%22Knorr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%20S.%22%2C%22lastName%22%3A%22Wexler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%22%2C%22lastName%22%3A%22Fuller%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Vitamin%20C%20has%20been%20previously%20studied%20for%20use%20with%20acute%20and%20chronic%20Epstein-Barr%20Virus%20%28EBV%29%20and%20hepatitis%20C.%20However%2C%20it%20has%20never%20been%20evaluated%20for%20its%20impact%20on%20EBV%20induced%20hepatitis.%20In%20this%20case%20report%2C%20we%20present%20a%20patient%27s%20history%20with%20EBV%20induced%20hepatitis%20treated%20with%20high%20dose%20vitamin%20C.%5CnMETHODS%3A%20A%2036-year-old%20female%20presented%20to%20the%20National%20University%20of%20Natural%20Medicine%20Health%20Center%20with%20reactivated%20EBV-induced%20viral%20hepatitis.%20She%20reported%20severe%20fatigue%2C%20brain%20fog%2C%20maintenance%20and%20initiation%20insomnia%2C%20periocular%20hyperpigmentation%2C%20blurry%20vision%2C%20and%20decreased%20concentration.%20The%20patient%27s%20diagnosis%20was%20confirmed%20with%20a%20diagnostic%20evaluation%20of%20her%20EBV%20titers%20and%20liver%20enzymes%2C%20all%20of%20which%20were%20elevated.%20After%20assessing%20for%20contraindications%2C%20the%20patient%20was%20treated%20with%20intravenous%20%28IV%29%20vitamin%20C%20starting%20at%20a%2010g%20dose%20and%20increasing%20weekly%20for%203%20weeks%20to%20a%20dose%20of%2025g.%5CnRESULTS%3A%20After%2012%20weeks%20of%20treatment%20with%20high%20dose%20IV%20vitamin%20C%2C%20as%20well%20as%20other%20immune-supportive%20nutrient%20therapy%2C%20the%20patient%20reported%20a%20decrease%20in%20fatigue%20severity%2C%20brain%20fog%2C%20vision%20disturbances%2C%20exercise%20limitations%2C%20and%20insomnia%20severity.%5CnDISCUSSION%3A%20We%20recommend%20that%20physicians%20consider%20the%20administration%20of%20high-dose%20IV%20vitamin%20C%20for%20all%20concurrent%20cases%20of%20EBV%20and%20hepatitis%20in%20both%20acute%20and%20chronic%20conditions.%20As%20recognition%20of%20reactivated%20viral%20infections%20grows%2C%20high-dose%20IV%20vitamin%20C%20for%20other%20latent%20viral%20infections%20such%20as%20COVID-19%2C%20cytomegalovirus%2C%20herpes%20simplex%2C%20varicella%20zoster%2C%20and%20HIV%20should%20be%20considered.%22%2C%22date%22%3A%222023-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221546-993X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-01T13%3A35%3A53Z%22%7D%7D%2C%7B%22key%22%3A%228REUHYQ7%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zeng%20et%20al.%22%2C%22parsedDate%22%3A%222023-10-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EZeng%20Y%2C%20Liu%20Z%2C%20Xu%20F%2C%20Tang%20Z.%20Intravenous%20high-dose%20vitamin%20C%20monotherapy%20for%20sepsis%20and%20septic%20shock%3A%20A%20meta-analysis%20of%20randomized%20controlled%20trials.%20%3Ci%3EMedicine%20%28Baltimore%29%3C%5C%2Fi%3E.%202023%3B102%2842%29%3Ae35648.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMD.0000000000035648%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMD.0000000000035648%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intravenous%20high-dose%20vitamin%20C%20monotherapy%20for%20sepsis%20and%20septic%20shock%3A%20A%20meta-analysis%20of%20randomized%20controlled%20trials%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yiqian%22%2C%22lastName%22%3A%22Zeng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhao%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fei%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhanhong%22%2C%22lastName%22%3A%22Tang%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%5CnVitamin%20C%20has%20been%20used%20as%20an%20adjuvant%20in%20the%20treatment%20of%20sepsis%20and%20septic%20shock%3B%20however%2C%20its%20role%20remains%20controversial.%20This%20study%20aimed%20to%20assess%20the%20effectiveness%20of%20intravenous%20high-dose%20vitamin%20C%20in%20sepsis%20and%20septic%20shock%20patients%20by%20meta-analysis.%5Cn%5CnMethods%3A%5CnThe%20PubMed%2C%20Embase%2C%20and%20Cochrane%20Library%20electronic%20databases%20were%20searched%20to%20identify%20relevant%20studies.%20The%20primary%20outcome%20was%20defined%20as%20the%20short-term%20all-cause%20mortality%20rate.%20Secondary%20outcomes%20included%20duration%20of%20vasoactive%20drug%20use%2C%20intensive%20care%20unit%20length%20of%20stay%2C%20sequential%20organ%20failure%20assessment%20scores%20up%20to%2096%20hours%20after%20treatment%20and%2090-day%20mortality.%20Review%20Manager%20version%205.4%20was%20used%20to%20perform%20the%20meta-analysis.%20Relative%20risk%20and%20mean%20differences%20%28MD%29%20with%2095%25%20confidence%20intervals%20were%20determined%20using%20fixed-%20or%20random-effects%20models.%5Cn%5CnResults%3A%5CnEight%20randomized%20controlled%20trials%20%28RCTs%29%20comprising%201394%20patients%20were%20eligible%20for%20assessment.%20Overall%2C%20the%20pooled%20results%20showed%20that%20high-dose%20vitamin%20C%20decreased%20short-term%20all-cause%20mortality%20in%20patients%20with%20sepsis%2C%20but%20no%20significant%20differences%20were%20observed%20in%20patients%20with%20septic%20shock.%20Additionally%2C%20high-dose%20vitamin%20C%20was%20associated%20with%20decreased%20duration%20of%20vasoactive%20drug%20use%20in%20patients%20with%20sepsis%2C%20but%20not%20in%20patients%20with%20septic%20shock.%20However%2C%20it%20did%20not%20significantly%20affect%20the%20duration%20of%20intensive%20care%20unit%20stay%20in%20RCTs%20of%20patients%20with%20sepsis%20and%20septic%20shock.%20Additionally%2C%20it%20did%20not%20significantly%20affect%20sequential%20organ%20failure%20assessment%20scores%2096%20hours%20post-treatment%20or%2090-day%20mortality.%5Cn%5CnConclusion%3A%5CnThese%20results%20suggest%20that%20intravenous%20high-dose%20vitamin%20C%20may%20improve%20outcomes%20in%20patients%20with%20sepsis%2C%20but%20do%20not%20benefit%20patients%20with%20septic%20shock.%20Further%20RCTs%20and%20other%20studies%20should%20be%20conducted%20to%20determine%20whether%20vitamin%20C%20should%20be%20recommended%20as%20an%20adjunctive%20sepsis%20treatment.%22%2C%22date%22%3A%222023-10-20%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FMD.0000000000035648%22%2C%22ISSN%22%3A%220025-7974%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10589557%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-01T13%3A31%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22SZWA26QD%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hashemi%20et%20al.%22%2C%22parsedDate%22%3A%222023-10-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHashemi%20SA%2C%20Ghadimi%20Z%2C%20Ghaedi%20H%2C%20Hashemi%20A.%20The%20effects%20of%20eight%20weeks%20of%20aerobic%20training%20with%20vitamin%20C%20on%20the%20expression%20pathway%20of%20antioxidants%20in%20the%20hippocampus%20tissue%20of%20TMT%20induced%20Alzheimer%26%23x2019%3Bs%20disease%20rats.%20%3Ci%3EBrain%20Res%3C%5C%2Fi%3E.%202023%3B1822%3A148645.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.brainres.2023.148645%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.brainres.2023.148645%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effects%20of%20eight%20weeks%20of%20aerobic%20training%20with%20vitamin%20C%20on%20the%20expression%20pathway%20of%20antioxidants%20in%20the%20hippocampus%20tissue%20of%20TMT%20induced%20Alzheimer%27s%20disease%20rats%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seyed%20Ahmad%22%2C%22lastName%22%3A%22Hashemi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zahra%22%2C%22lastName%22%3A%22Ghadimi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hadi%22%2C%22lastName%22%3A%22Ghaedi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayoub%22%2C%22lastName%22%3A%22Hashemi%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Alzheimer%27s%20disease%20%28AD%29%20is%20one%20of%20the%20most%20common%20neurological%20disorders%20and%2C%20researchers%20believe%20that%20the%20impairment%20of%20oxidant-antioxidant%20system%20plays%20an%20important%20role%20in%20its%20progression.%20The%20PI3K%5C%2FNRF2%20pathway%20has%20particular%20importance%20in%20increasing%20the%20expression%20of%20antioxidants.%20Thus%20present%20study%20aimed%20to%20investigate%20the%20effect%20of%20eight%20weeks%20of%20aerobic%20training%20%28AT%29%20with%20vitamin%20C%20%28VC%29%20on%20the%20expression%20pathway%20of%20antioxidants%20in%20the%20hippocampus%20tissue%20of%20trimethyltin%20chloride%20%28TMT%29%20induced%20Alzheimer%27s%20Disease%20Rats.%5CnMETHODS%3A%20In%20this%20experimental%20study%2C%2028%20male%20Sprague-Dawley%20rats%20%28age%2014-16%5Cu00a0months%2C%20weight%20270-320%5Cu00a0g%29%20were%20injected%2010%5Cu00a0mg%5C%2Fkg%20TMT%20and%20were%20divided%20into%20%281%29%20TMT%20%28n%5Cu00a0%3D%5Cu00a07%29%2C%20%282%29%20TMT%5Cu00a0%2B%5Cu00a0VC%20%28n%5Cu00a0%3D%5Cu00a07%29%2C%20%283%29%20TMT%5Cu00a0%2B%5Cu00a0AT%20%28n%5Cu00a0%3D%5Cu00a07%29%20and%20%284%29%20TMT%5Cu00a0%2B%5Cu00a0VC%5Cu00a0%2B%5Cu00a0AT%20%28n%5Cu00a0%3D%5Cu00a07%29%20groups.%20Also%2C%207%20healthy%20rats%20without%20any%20intervention%20selected%20as%20healthy%20control%20%28HC%29%20group%20to%20investigate%20the%20effects%20of%20TMT%20on%20research%20variables.%20Groups%203%20and%204%20ran%20on%20the%20treadmill%20for%20eight%20weeks%2C%20for%2015-48%5Cu00a0min%20at%20a%20speed%20of%2010-24%5Cu00a0m%5C%2Fmin.%20Also%2C%20groups%202%20and%204%20received%204%5Cu00a0mg%5C%2Fkg%20VC%20orally.%20To%20measure%20PI3K%2C%20Nrf2%2C%20SOD%20and%20catalase%20in%20the%20hippocampus%20tissue%20of%20rats%2C%20ELISA%20method%20were%20used.%20To%20analyze%20the%20data%2C%20one-way%20analysis%20of%20variance%20with%20Tukey%27s%20post-%20hoc%20tests%20were%20used%20%28P%5Cu00a0%5Cu2264%5Cu00a00.05%29.%5CnRESULTS%3A%20The%20hippocampal%20values%20of%20Nrf2%20and%20SOD%20in%20TMT%5Cu00a0%2B%5Cu00a0VC%2C%20TMT%5Cu00a0%2B%5Cu00a0AT%20and%20TMT%5Cu00a0%2B%5Cu00a0VC%5Cu00a0%2B%5Cu00a0AT%20groups%20were%20higher%20than%20TMT%20group%20%28P%5Cu00a0%3D%5Cu00a00.001%29.%20Catalase%20in%20TMT%5Cu00a0%2B%5Cu00a0AT%20and%20TMT%5Cu00a0%2B%5Cu00a0VC%5Cu00a0%2B%5Cu00a0AT%20groups%20was%20higher%20than%20TMT%20group%20%28P%5Cu00a0%3D%5Cu00a00.001%29.%20Also%2C%20catalase%20and%20PI3K%20were%20higher%20in%20the%20TMT%5Cu00a0%2B%5Cu00a0VC%5Cu00a0%2B%5Cu00a0AT%20group%20than%20the%20TMT%5Cu00a0%2B%5Cu00a0VC%20group%20%28P%5Cu00a0%3D%5Cu00a00.05%29.%20PI3K%20levels%20of%20TMT%5Cu00a0%2B%5Cu00a0VC%5Cu00a0%2B%5Cu00a0AT%20group%20were%20higher%20than%20TMT%5Cu00a0%2B%5Cu00a0AT%20group%20%28P%5Cu00a0%3D%5Cu00a00.02%29.%5CnCONCLUSION%3A%20It%20seems%20that%20AT%20and%20VC%2C%20both%20alone%20and%20in%20combination%2C%20play%20a%20role%20in%20improving%20the%20transcription%20pathway%20of%20antioxidants%20in%20the%20hippocampus%20tissue%20of%20TMT%20induced%20Alzheimer%27s%20disease%20Rats.%20Therefore%2C%20the%20combination%20of%20these%20two%20interventions%20is%20suggested%20to%20improve%20the%20antioxidant%20system.%22%2C%22date%22%3A%222023-10-21%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.brainres.2023.148645%22%2C%22ISSN%22%3A%221872-6240%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-01T13%3A19%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22H27CV7NU%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lankadeva%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-27%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELankadeva%20YR%2C%20Lane%20DJR%2C%20Ow%20CPC%2C%20Story%20DA%2C%20Plummer%20MP%2C%20May%20CN.%20LOVIT%20or%20leave%20it%3A%20The%20vitamin%20C%20debate%20continues.%20%3Ci%3ECrit%20Care%20Resusc%3C%5C%2Fi%3E.%202023%3B25%282%29%3A63-64.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ccrj.2023.05.001%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ccrj.2023.05.001%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22LOVIT%20or%20leave%20it%3A%20The%20vitamin%20C%20debate%20continues%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yugeesh%20R.%22%2C%22lastName%22%3A%22Lankadeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Darius%20JR.%22%2C%22lastName%22%3A%22Lane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Connie%20PC.%22%2C%22lastName%22%3A%22Ow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A.%22%2C%22lastName%22%3A%22Story%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20P.%22%2C%22lastName%22%3A%22Plummer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clive%20N.%22%2C%22lastName%22%3A%22May%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-6-27%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ccrj.2023.05.001%22%2C%22ISSN%22%3A%221441-2772%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10581254%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-01T13%3A15%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22PECP5KRX%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lankadeva%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELankadeva%20YR%2C%20Lane%20DJ%2C%20Ow%20CP%2C%20Story%20DA%2C%20Plummer%20MP%2C%20May%20CN.%20LOVIT%20or%20leave%20it%3A%20The%20vitamin%20C%20debate%20continues.%20%3Ci%3ECrit%20Care%20Resusc%3C%5C%2Fi%3E.%202023%3B25%282%29%3A63-64.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ccrj.2023.05.001%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ccrj.2023.05.001%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22LOVIT%20or%20leave%20it%3A%20The%20vitamin%20C%20debate%20continues%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yugeesh%20R.%22%2C%22lastName%22%3A%22Lankadeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Darius%20Jr%22%2C%22lastName%22%3A%22Lane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Connie%20Pc%22%2C%22lastName%22%3A%22Ow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20A.%22%2C%22lastName%22%3A%22Story%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20P.%22%2C%22lastName%22%3A%22Plummer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clive%20N.%22%2C%22lastName%22%3A%22May%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ccrj.2023.05.001%22%2C%22ISSN%22%3A%221441-2772%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-11-01T13%3A15%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22A7TZCMCW%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hickey%20and%20Roberts%22%2C%22parsedDate%22%3A%222005-09%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHickey%20S%2C%20Roberts%20H.%20Misleading%20Information%20on%20the%20Properties%20of%20Vitamin%20C.%20%3Ci%3EPLoS%20Medicine%3C%5C%2Fi%3E.%202005%3B2%289%29.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.0020307%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.0020307%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Misleading%20Information%20on%20the%20Properties%20of%20Vitamin%20C%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steve%22%2C%22lastName%22%3A%22Hickey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hilary%22%2C%22lastName%22%3A%22Roberts%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222005%5C%2F09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pmed.0020307%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC1236801%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-10-30T19%3A48%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22GCGNJZ7Y%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hemil%5Cu00e4%20and%20Chalker%22%2C%22parsedDate%22%3A%222013%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHemil%26%23xE4%3B%20H%2C%20Chalker%20E.%20Vitamin%20C%20for%20preventing%20and%20treating%20the%20common%20cold.%20%3Ci%3ECochrane%20Database%20of%20Systematic%20Reviews%3C%5C%2Fi%3E.%202013%3B%281%29.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F14651858.CD000980.pub4%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F14651858.CD000980.pub4%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vitamin%20C%20for%20preventing%20and%20treating%20the%20common%20cold%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harri%22%2C%22lastName%22%3A%22Hemil%5Cu00e4%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Chalker%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222013%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2F14651858.CD000980.pub4%22%2C%22ISSN%22%3A%221465-1858%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.cochranelibrary.com%5C%2Fcdsr%5C%2Fdoi%5C%2F10.1002%5C%2F14651858.CD000980.pub4%5C%2Fdetailed-comment%5C%2Fru%3FmessageId%3D415275088%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-10-30T19%3A48%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22YB5KJLU8%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ran%20et%20al.%22%2C%22parsedDate%22%3A%222018-07-05%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ERan%20L%2C%20Zhao%20W%2C%20Wang%20J%2C%20et%20al.%20Extra%20Dose%20of%20Vitamin%20C%20Based%20on%20a%20Daily%20Supplementation%20Shortens%20the%20Common%20Cold%3A%20A%20Meta-Analysis%20of%209%20Randomized%20Controlled%20Trials.%20%3Ci%3EBiomed%20Res%20Int%3C%5C%2Fi%3E.%20Published%20online%20July%205%2C%202018%3A1837634.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1155%5C%2F2018%5C%2F1837634%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1155%5C%2F2018%5C%2F1837634%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extra%20Dose%20of%20Vitamin%20C%20Based%20on%20a%20Daily%20Supplementation%20Shortens%20the%20Common%20Cold%3A%20A%20Meta-Analysis%20of%209%20Randomized%20Controlled%20Trials%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Li%22%2C%22lastName%22%3A%22Ran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenli%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jingxia%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongwu%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ye%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yiider%22%2C%22lastName%22%3A%22Tseng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huaien%22%2C%22lastName%22%3A%22Bu%22%7D%5D%2C%22abstractNote%22%3A%22Aim%5Cn%20To%20investigate%20whether%20vitamin%20C%20is%20effective%20in%20the%20treatment%20of%20the%20common%20cold.%5Cn%5Cn%20Method%5Cn%20After%20systematically%20searching%20the%20National%20Library%20of%20Medicine%20%28PubMed%29%2C%20Cochrane%20Library%2C%20Elsevier%2C%20China%20National%20Knowledge%20Infrastructure%20%28CNKI%29%2C%20VIP%20databases%2C%20and%20WANFANG%20databases%2C%209%20randomized%20placebo-controlled%20trials%20were%20included%20in%20our%20meta-analysis%20in%20RevMan%205.3%20software%2C%20all%20of%20which%20were%20in%20English.%5Cn%5Cn%20Results%5Cn%20In%20the%20evaluation%20of%20vitamin%20C%2C%20administration%20of%20extra%20therapeutic%20doses%20at%20the%20onset%20of%20cold%20despite%20routine%20supplementation%20was%20found%20to%20help%20reduce%20its%20duration%20%28mean%20difference%20%28MD%29%20%3D%20-0.56%2C%2095%25%20confidence%20interval%20%28CI%29%20%5B-1.03%2C%20-0.10%5D%2C%20and%20P%20%3D%200.02%29%2C%20shorten%20the%20time%20of%20confinement%20indoors%20%28MD%20%3D%20-0.41%2C%2095%25%20CI%20%5B-0.62%2C%20-0.19%5D%2C%20and%20P%20%3D%200.0002%29%2C%20and%20relieve%20the%20symptoms%20associated%20with%20it%2C%20including%20chest%20pain%20%28MD%20%3D%20-0.40%2C%2095%25%20CI%20%5B-0.77%2C%20-0.03%5D%2C%20and%20P%20%3D%200.03%29%2C%20fever%20%28MD%20%3D%20-0.45%2C%2095%25%20CI%20%5B-0.78%2C%20-0.11%5D%2C%20and%20P%20%3D%200.009%29%2C%20and%20chills%20%28MD%20%3D%20-0.36%2C%2095%25%20CI%20%5B-0.65%2C%20-0.07%5D%2C%20and%20P%20%3D%200.01%29.%5Cn%5Cn%20Conclusions%5Cn%20Extra%20doses%20of%20vitamin%20C%20could%20benefit%20some%20patients%20who%20contract%20the%20common%20cold%20despite%20taking%20daily%20vitamin%20C%20supplements.%22%2C%22date%22%3A%222018-7-5%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1155%5C%2F2018%5C%2F1837634%22%2C%22ISSN%22%3A%222314-6133%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC6057395%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-10-30T18%3A56%3A18Z%22%7D%7D%2C%7B%22key%22%3A%223AIR7V5U%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cathcart%22%2C%22parsedDate%22%3A%221981%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ECathcart%20R.%20The%20Method%20of%20Determining%20Proper%20Doses%20of%20Vitamin%20C%20for%20the%20Treatment%20of%20Disease%20by%20Titrating%20to%20Bowel%20Tolerance.%20%3Ci%3EJournal%20of%20Orthomolecular%20Psychiatry%3C%5C%2Fi%3E.%201981%3B10%282%29%3A125-132.%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Method%20of%20Determining%20Proper%20Doses%20of%20Vitamin%20C%20for%20the%20Treatment%20of%20Disease%20by%20Titrating%20to%20Bowel%20Tolerance%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Cathcart%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%221981%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-10-30T18%3A11%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22247ZBZYA%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22DeGeorge%20et%20al.%22%2C%22parsedDate%22%3A%222019-09-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EDeGeorge%20KC%2C%20Ring%20DJ%2C%20Dalrymple%20SN.%20Treatment%20of%20the%20Common%20Cold.%20%3Ci%3Eafp%3C%5C%2Fi%3E.%202019%3B100%285%29%3A281-289.%20Accessed%20January%2016%2C%202023.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.aafp.org%5C%2Fpubs%5C%2Fafp%5C%2Fissues%5C%2F2019%5C%2F0901%5C%2Fp281.html%27%3Ehttps%3A%5C%2F%5C%2Fwww.aafp.org%5C%2Fpubs%5C%2Fafp%5C%2Fissues%5C%2F2019%5C%2F0901%5C%2Fp281.html%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Treatment%20of%20the%20Common%20Cold%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharine%20C.%22%2C%22lastName%22%3A%22DeGeorge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20J.%22%2C%22lastName%22%3A%22Ring%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20N.%22%2C%22lastName%22%3A%22Dalrymple%22%7D%5D%2C%22abstractNote%22%3A%22Acute%20upper%20respiratory%20tract%20infection%2C%20also%20called%20the%20common%20cold%2C%20is%20the%20most%20common%20acute%20illness%20in%20the%20United%20States.%20Informing%20patients%20about%20the%20self-limited%20nature%20of%20this%20illness%20can%20help%20manage%20expectations%2C%20limit%20antibiotic%20use%2C%20and%20avoid%20over-the-counter%20purchases%20that%20are%20unlikely%20to%20help.%20Treatments%20with%20proven%20effectiveness%20for%20cold%20symptoms%20in%20adults%20include%20over-the-counter%20analgesics%2C%20zinc%2C%20nasal%20decongestants%20with%20or%20without%20antihistamines%2C%20and%20intranasal%20ipratropium.%20The%20only%20safe%20and%20effective%20treatments%20for%20children%20are%20analgesics%2C%20acetylcysteine%2C%20honey%2C%20nasal%20saline%20irrigation%2C%20intranasal%20ipratropium%2C%20and%20menthol%20rub.%22%2C%22date%22%3A%222019%5C%2F09%5C%2F01%22%2C%22language%22%3A%22en-US%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aafp.org%5C%2Fpubs%5C%2Fafp%5C%2Fissues%5C%2F2019%5C%2F0901%5C%2Fp281.html%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-10-30T17%3A50%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22AFGGUHJZ%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22parsedDate%22%3A%222023-08-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EOptical%20stimulation%20of%20mitochondria%20reduces%20blood%20glucose%20levels.%20doi%3A10.21203%5C%2Frs.3.rs-3275287%5C%2Fv1%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Optical%20stimulation%20of%20mitochondria%20reduces%20blood%20glucose%20levels%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22Mitochondria%20regulate%20metabolism%2C%20but%20solar%20light%20influences%20its%20rate.%20Red%20light%20increases%20mitochondrial%20membrane%20potentials%20and%20ATP%20production%20and%20may%20increase%20glucose%20demand.%20Here%20we%20show%2C%20with%20a%20glucose%20tolerance%20test%2C%20that%20red%20light%20exposure%20in%20normal%20subjects%20significantly%20reduces%20blood%20s...%22%2C%22date%22%3A%222023-08-28%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.researchsquare.com%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-10-01T11%3A05%3A31Z%22%7D%7D%2C%7B%22key%22%3A%225R7ZSNGJ%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aronica%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAronica%20L%2C%20Landry%20MJ%2C%20Rigdon%20J%2C%20Gardner%20CD.%20Weight%2C%20insulin%20resistance%2C%20blood%20lipids%2C%20and%20diet%20quality%20changes%20associated%20with%20ketogenic%20and%20ultra%20low-fat%20dietary%20patterns%3A%20a%20secondary%20analysis%20of%20the%20DIETFITS%20randomized%20clinical%20trial.%20%3Ci%3EFrontiers%20in%20Nutrition%3C%5C%2Fi%3E.%202023%3B10.%20Accessed%20July%2013%2C%202023.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1220020%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1220020%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Weight%2C%20insulin%20resistance%2C%20blood%20lipids%2C%20and%20diet%20quality%20changes%20associated%20with%20ketogenic%20and%20ultra%20low-fat%20dietary%20patterns%3A%20a%20secondary%20analysis%20of%20the%20DIETFITS%20randomized%20clinical%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucia%22%2C%22lastName%22%3A%22Aronica%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20J.%22%2C%22lastName%22%3A%22Landry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Rigdon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20D.%22%2C%22lastName%22%3A%22Gardner%22%7D%5D%2C%22abstractNote%22%3A%22BackgroundThe%20DIETFITS%20trial%20reported%20no%20significant%20difference%20in%2012-month%20weight%20loss%20between%20a%20healthy%20low-fat%20and%20healthy%20low-carbohydrate%20diet.%20Participants%20were%20instructed%20to%20restrict%20fat%20or%20carbohydrates%20to%20levels%20consistent%20with%20a%20ketogenic%20or%20ultra%20low-fat%20diet%20for%202%20%5Cu2009months%20and%20to%20subsequently%20increase%20intakes%20until%20they%20achieved%20a%20comfortable%20maintenance%20level.ObjectiveTo%20compare%203-%20and%2012-month%20changes%20in%20body%20weight%20and%20cardiometabolic%20risk%20factors%20between%20a%20subsample%20of%20participants%20who%20reported%203-month%20fat%20or%20carbohydrates%20intakes%20consistent%20with%20either%20a%20ketogenic-like%20diet%20%28KLD%29%20or%20ultra%20low-fat%20diet%20%28ULF%29.Design3-month%20and%2012-month%20weight%20and%20risk%20factor%20outcomes%20were%20compared%20between%20KLD%20%28n%5Cu2009%3D%5Cu200918%29%20and%20ULF%20%28n%5Cu2009%3D%5Cu200921%29%20sub-groups%20of%20DIETFITS%20participants%20%28selected%20from%20n%5Cu2009%3D%5Cu2009609%2C%20healthy%20overweight%5C%2Fobese%2C%20aged%2018%5Cu201350%20%5Cu2009years%29.ResultsLess%20than%2010%25%20of%20DIETFITS%20participants%20met%20KLD%20or%20ULF%20criteria%20at%203-months.%20Both%20groups%20achieved%20similar%20weight%20loss%20and%20insulin%20resistance%20improvements%20at%203-months%20and%20maintained%20them%20at%2012-%20months.%20Significant%20differences%20at%203-months%20included%20a%20transient%20~12%25%20increase%20in%20LDL%20cholesterol%20%28LDL-C%29%20for%20KLD%20with%20a%20concomitant%20greater%20reduction%20in%20log%28TG%5C%2FHDL%29%2C%20a%20measure%20of%20LDL-C%5Cu2019s%20atherogenic%20potential.%20The%20latter%20was%20maintained%20at%2012-months%2C%20despite%20substantial%20diet%20recidivism%20for%20both%20groups%2C%20whereas%20LDL-C%20levels%20were%20similar%20for%20ULF%20at%20baseline%20and%2012-months.%20KLD%20participants%20achieved%20and%20maintained%20the%20greatest%20reductions%20in%20added%20sugars%20and%20refined%20grains%20at%203-%20months%20and%2012-months%2C%20whereas%20ULF%20participants%20reported%20a%2050%25%20increase%20in%20refined%20grains%20intake%20from%20baseline%20to%2012-months.ConclusionAmong%20the%20~10%25%20of%20study%20participants%20that%20achieved%20the%20most%20extreme%20restriction%20of%20dietary%20fat%20vs.%20carbohydrate%20after%203%20%5Cu2009months%2C%20weight%20loss%20and%20improvement%20in%20insulin%20sensitivity%20were%20substantial%20and%20similar%20between%20groups.%20At%2012%5Cu2009%20months%2C%20after%20considerable%20dietary%20recidivism%2C%20the%20few%20significant%20differences%20in%20diet%20quality%20and%20blood%20lipid%20parameters%20tended%20to%20favor%20KLD%20over%20ULF.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222296-861X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1220020%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-07-13T17%3A30%3A06Z%22%7D%7D%2C%7B%22key%22%3A%229U4B4QZU%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Diamond%20et%20al.%22%2C%22parsedDate%22%3A%222022-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EDiamond%20DM%2C%20Bikman%20BT%2C%20Mason%20P.%20Statin%20therapy%20is%20not%20warranted%20for%20a%20person%20with%20high%20LDL-cholesterol%20on%20a%20low-carbohydrate%20diet.%20%3Ci%3ECurrent%20Opinion%20in%20Endocrinology%2C%20Diabetes%20and%20Obesity%3C%5C%2Fi%3E.%202022%3B29%285%29%3A497.%20Accessed%20June%2025%2C%202023.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2Fco-endocrinology%5C%2FFulltext%5C%2F2022%5C%2F10000%5C%2FStatin_therapy_is_not_warranted_for_a_person_with.14.aspx%27%3Ehttps%3A%5C%2F%5C%2Fjournals.lww.com%5C%2Fco-endocrinology%5C%2FFulltext%5C%2F2022%5C%2F10000%5C%2FStatin_therapy_is_not_warranted_for_a_person_with.14.aspx%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Statin%20therapy%20is%20not%20warranted%20for%20a%20person%20with%20high%20LDL-cholesterol%20on%20a%20low-carbohydrate%20diet%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20M.%22%2C%22lastName%22%3A%22Diamond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20T.%22%2C%22lastName%22%3A%22Bikman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Mason%22%7D%5D%2C%22abstractNote%22%3A%22Purpose%20of%20review%5Cu00a0%5Cn%20%20%20%20%20%20%20%20%20%20Although%20there%20is%20an%20extensive%20literature%20on%20the%20efficacy%20of%20the%20low%20carbohydrate%20diet%20%28LCD%29%20for%20weight%20loss%20and%20in%20the%20management%20of%20type%202%20diabetes%2C%20concerns%20have%20been%20raised%20that%20the%20LCD%20may%20increase%20cardiovascular%20disease%20%28CVD%29%20risk%20by%20increasing%20the%20level%20of%20low-density%20lipoprotein%20cholesterol%20%28LDL-C%29.%20We%20have%20assessed%20the%20value%20of%20LDL-C%20as%20a%20CVD%20risk%20factor%2C%20as%20well%20as%20effects%20of%20the%20LCD%20on%20other%20CVD%20risk%20factors.%20We%20have%20also%20reviewed%20findings%20that%20provide%20guidance%20as%20to%20whether%20statin%20therapy%20would%20be%20beneficial%20for%20individuals%20with%20high%20LDL-C%20on%20an%20LCD.%5Cn%20%20%20%20%20%20%20%20%20%20Recent%20findings%5Cu00a0%5Cn%20%20%20%20%20%20%20%20%20%20Multiple%20longitudinal%20trials%20have%20demonstrated%20the%20safety%20and%20effectiveness%20of%20the%20LCD%2C%20while%20also%20providing%20evidence%20of%20improvements%20in%20the%20most%20reliable%20CVD%20risk%20factors.%20Recent%20findings%20have%20also%20confirmed%20how%20ineffective%20LDL-C%20is%20in%20predicting%20CVD%20risk.%5Cn%20%20%20%20%20%20%20%20%20%20Summary%5Cu00a0%5Cn%20%20%20%20%20%20%20%20%20%20Extensive%20research%20has%20demonstrated%20the%20efficacy%20of%20the%20LCD%20to%20improve%20the%20most%20robust%20CVD%20risk%20factors%2C%20such%20as%20hyperglycemia%2C%20hypertension%2C%20and%20atherogenic%20dyslipidemia.%20Our%20review%20of%20the%20literature%20indicates%20that%20statin%20therapy%20for%20both%20primary%20and%20secondary%20prevention%20of%20CVD%20is%20not%20warranted%20for%20individuals%20on%20an%20LCD%20with%20elevated%20LDL-C%20who%20have%20achieved%20a%20low%20triglyceride%5C%2FHDL%20ratio.%22%2C%22date%22%3A%22October%202022%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221752-296X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2Fco-endocrinology%5C%2FFulltext%5C%2F2022%5C%2F10000%5C%2FStatin_therapy_is_not_warranted_for_a_person_with.14.aspx%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-06-25T21%3A46%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22WM9AZ55F%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22McCullough%20et%20al.%22%2C%22parsedDate%22%3A%222019-05-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMcCullough%20PJ%2C%20Lehrer%20DS%2C%20Amend%20J.%20Daily%20oral%20dosing%20of%20vitamin%20D3%20using%205000%20TO%2050%2C000%20international%20units%20a%20day%20in%20long-term%20hospitalized%20patients%3A%20Insights%20from%20a%20seven%20year%20experience.%20%3Ci%3EThe%20Journal%20of%20Steroid%20Biochemistry%20and%20Molecular%20Biology%3C%5C%2Fi%3E.%202019%3B189%3A228-239.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jsbmb.2018.12.010%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jsbmb.2018.12.010%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Daily%20oral%20dosing%20of%20vitamin%20D3%20using%205000%20TO%2050%2C000%20international%20units%20a%20day%20in%20long-term%20hospitalized%20patients%3A%20Insights%20from%20a%20seven%20year%20experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J.%22%2C%22lastName%22%3A%22McCullough%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Douglas%20S.%22%2C%22lastName%22%3A%22Lehrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%22%2C%22lastName%22%3A%22Amend%22%7D%5D%2C%22abstractNote%22%3A%22Vitamin%20D3%20is%20a%20secosteroid%20hormone%20produced%20in%20the%20skin%20in%20amounts%20estimated%20up%20to%2025%2C000%20international%20units%20%28IUs%29%20a%20day%20by%20the%20action%20of%20UVB%20radiation%20on%207-dehydrocholesterol.%20Vitamin%20D%20deficiency%20is%20common%20due%20to%20both%20lack%20of%20adequate%20sun%20exposure%20to%20the%20skin%2C%20and%20because%20vitamin%20D%20is%20present%20in%20very%20few%20food%20sources.%20Deficiency%20is%20strongly%20linked%20to%20increased%20risk%20for%20a%20multitude%20of%20diseases%2C%20several%20of%20which%20have%20historically%20been%20shown%20to%20improve%20dramatically%20with%20either%20adequate%20UVB%20exposure%20to%20the%20skin%2C%20or%20to%20oral%20or%20topical%20supplementation%20with%20vitamin%20D.%20These%20diseases%20include%20asthma%2C%20psoriasis%2C%20rheumatoid%20arthritis%2C%20rickets%20and%20tuberculosis.%20All%20patients%20in%20our%20hospital%20have%20been%20routinely%20screened%20on%20admission%20for%20vitamin%20D%20deficiency%20since%20July%202011%2C%20and%20offered%20supplementation%20to%20either%20correct%20or%20prevent%20deficiency.%20During%20this%20time%2C%20we%20have%20admitted%20over%204700%20patients%2C%20the%20vast%20majority%20of%20whom%20agreed%20to%20supplementation%20with%20either%205000%20or%2010%2C000%20IUs%5C%2Fday.%20Due%20to%20disease%20concerns%2C%20a%20few%20agreed%20to%20larger%20amounts%2C%20ranging%20from%2020%2C000%20to%2050%2C000%20IUs%5C%2Fday.%20There%20have%20been%20no%20cases%20of%20vitamin%20D3%20induced%20hypercalcemia%20or%20any%20adverse%20events%20attributable%20to%20vitamin%20D3%20supplementation%20in%20any%20patient.%20Three%20patients%20with%20psoriasis%20showed%20marked%20clinical%20improvement%20in%20their%20skin%20using%2020%2C000%20to%2050%2C000%20IUs%5C%2Fday.%20Analysis%20of%20777%20recently%20tested%20patients%20%28new%20and%20long-term%29%20not%20on%20D3%20revealed%2028.7%25%20with%2025-hydroxyvitaminD3%20%2825OHD3%29%20blood%20levels%20%3C%2020%5Cu2009ng%5C%2Fml%2C%2064.1%25%20%3C%2030%5Cu2009ng%5C%2Fml%2C%20a%20mean%2025OHD3%20level%20of%2027.1%5Cu2009ng%5C%2Fml%2C%20with%20a%20range%20from%204.9%20to%2074.8%5Cu2009ng%5C%2Fml.%20Analysis%20of%20418%20inpatients%20on%20D3%20long%20enough%20to%20develop%2025OHD3%20blood%20levels%20%3E%2074.4%5Cu2009ng%5C%2Fml%20showed%20a%20mean%2025OHD3%20level%20of%20118.9%5Cu2009ng%5C%2Fml%2C%20with%20a%20range%20from%2074.4%20to%20384.8%5Cu2009ng%5C%2Fml.%20The%20average%20serum%20calcium%20level%20in%20these%202%20groups%20was%209.5%20%28no%20D3%29%20vs%209.6%20%28D3%29%2C%20with%20ranges%20of%208.4%20to%2010.7%20%28no%20D3%29%20vs%208.6%20to%2010.7%5Cu2009mg%5C%2Fdl%20%28D3%29%2C%20after%20excluding%20patients%20with%20other%20causes%20of%20hypercalcemia.%20The%20average%20intact%20parathyroid%20hormone%20levels%20were%2024.2%5Cu2009pg%5C%2Fml%20%28D3%29%20vs.%2030.2%5Cu2009pg%5C%2Fml%20%28no%20D3%29.%20In%20summary%2C%20long-term%20supplementation%20with%20vitamin%20D3%20in%20doses%20ranging%20from%205000%20to%2050%2C000%20IUs%5C%2Fday%20appears%20to%20be%20safe.%22%2C%22date%22%3A%222019-05-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jsbmb.2018.12.010%22%2C%22ISSN%22%3A%220960-0760%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0960076018306228%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-05-16T12%3A33%3A03Z%22%7D%7D%2C%7B%22key%22%3A%223WRXTH83%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22McCullough%20et%20al.%22%2C%22parsedDate%22%3A%222019-05-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMcCullough%20PJ%2C%20Lehrer%20DS%2C%20Amend%20J.%20Daily%20oral%20dosing%20of%20vitamin%20D3%20using%205000%20TO%2050%2C000%20international%20units%20a%20day%20in%20long-term%20hospitalized%20patients%3A%20Insights%20from%20a%20seven%20year%20experience.%20%3Ci%3EThe%20Journal%20of%20Steroid%20Biochemistry%20and%20Molecular%20Biology%3C%5C%2Fi%3E.%202019%3B189%3A228-239.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jsbmb.2018.12.010%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jsbmb.2018.12.010%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Daily%20oral%20dosing%20of%20vitamin%20D3%20using%205000%20TO%2050%2C000%20international%20units%20a%20day%20in%20long-term%20hospitalized%20patients%3A%20Insights%20from%20a%20seven%20year%20experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20J.%22%2C%22lastName%22%3A%22McCullough%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Douglas%20S.%22%2C%22lastName%22%3A%22Lehrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%22%2C%22lastName%22%3A%22Amend%22%7D%5D%2C%22abstractNote%22%3A%22Vitamin%20D3%20is%20a%20secosteroid%20hormone%20produced%20in%20the%20skin%20in%20amounts%20estimated%20up%20to%2025%2C000%20international%20units%20%28IUs%29%20a%20day%20by%20the%20action%20of%20UVB%20radiation%20on%207-dehydrocholesterol.%20Vitamin%20D%20deficiency%20is%20common%20due%20to%20both%20lack%20of%20adequate%20sun%20exposure%20to%20the%20skin%2C%20and%20because%20vitamin%20D%20is%20present%20in%20very%20few%20food%20sources.%20Deficiency%20is%20strongly%20linked%20to%20increased%20risk%20for%20a%20multitude%20of%20diseases%2C%20several%20of%20which%20have%20historically%20been%20shown%20to%20improve%20dramatically%20with%20either%20adequate%20UVB%20exposure%20to%20the%20skin%2C%20or%20to%20oral%20or%20topical%20supplementation%20with%20vitamin%20D.%20These%20diseases%20include%20asthma%2C%20psoriasis%2C%20rheumatoid%20arthritis%2C%20rickets%20and%20tuberculosis.%20All%20patients%20in%20our%20hospital%20have%20been%20routinely%20screened%20on%20admission%20for%20vitamin%20D%20deficiency%20since%20July%202011%2C%20and%20offered%20supplementation%20to%20either%20correct%20or%20prevent%20deficiency.%20During%20this%20time%2C%20we%20have%20admitted%20over%204700%20patients%2C%20the%20vast%20majority%20of%20whom%20agreed%20to%20supplementation%20with%20either%205000%20or%2010%2C000%20IUs%5C%2Fday.%20Due%20to%20disease%20concerns%2C%20a%20few%20agreed%20to%20larger%20amounts%2C%20ranging%20from%2020%2C000%20to%2050%2C000%20IUs%5C%2Fday.%20There%20have%20been%20no%20cases%20of%20vitamin%20D3%20induced%20hypercalcemia%20or%20any%20adverse%20events%20attributable%20to%20vitamin%20D3%20supplementation%20in%20any%20patient.%20Three%20patients%20with%20psoriasis%20showed%20marked%20clinical%20improvement%20in%20their%20skin%20using%2020%2C000%20to%2050%2C000%20IUs%5C%2Fday.%20Analysis%20of%20777%20recently%20tested%20patients%20%28new%20and%20long-term%29%20not%20on%20D3%20revealed%2028.7%25%20with%2025-hydroxyvitaminD3%20%2825OHD3%29%20blood%20levels%20%3C%2020%5Cu2009ng%5C%2Fml%2C%2064.1%25%20%3C%2030%5Cu2009ng%5C%2Fml%2C%20a%20mean%2025OHD3%20level%20of%2027.1%5Cu2009ng%5C%2Fml%2C%20with%20a%20range%20from%204.9%20to%2074.8%5Cu2009ng%5C%2Fml.%20Analysis%20of%20418%20inpatients%20on%20D3%20long%20enough%20to%20develop%2025OHD3%20blood%20levels%20%3E%2074.4%5Cu2009ng%5C%2Fml%20showed%20a%20mean%2025OHD3%20level%20of%20118.9%5Cu2009ng%5C%2Fml%2C%20with%20a%20range%20from%2074.4%20to%20384.8%5Cu2009ng%5C%2Fml.%20The%20average%20serum%20calcium%20level%20in%20these%202%20groups%20was%209.5%20%28no%20D3%29%20vs%209.6%20%28D3%29%2C%20with%20ranges%20of%208.4%20to%2010.7%20%28no%20D3%29%20vs%208.6%20to%2010.7%5Cu2009mg%5C%2Fdl%20%28D3%29%2C%20after%20excluding%20patients%20with%20other%20causes%20of%20hypercalcemia.%20The%20average%20intact%20parathyroid%20hormone%20levels%20were%2024.2%5Cu2009pg%5C%2Fml%20%28D3%29%20vs.%2030.2%5Cu2009pg%5C%2Fml%20%28no%20D3%29.%20In%20summary%2C%20long-term%20supplementation%20with%20vitamin%20D3%20in%20doses%20ranging%20from%205000%20to%2050%2C000%20IUs%5C%2Fday%20appears%20to%20be%20safe.%22%2C%22date%22%3A%222019-05-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jsbmb.2018.12.010%22%2C%22ISSN%22%3A%220960-0760%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0960076018306228%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-05-16T12%3A31%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22F6LGPLN6%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Amzali%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-30%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAmzali%20S%2C%20Wilson%20VD%2C%20Bommart%20S%2C%20et%20al.%20Nutritional%20Status%20of%20Patients%20with%20Facioscapulohumeral%20Muscular%20Dystrophy.%20%3Ci%3ENutrients%3C%5C%2Fi%3E.%202023%3B15%287%29%3A1673.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fnu15071673%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fnu15071673%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nutritional%20Status%20of%20Patients%20with%20Facioscapulohumeral%20Muscular%20Dystrophy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sedda%22%2C%22lastName%22%3A%22Amzali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vinicius%20Dias%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Bommart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Christine%22%2C%22lastName%22%3A%22Picot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Galas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Mercier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Poucheret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Paul%22%2C%22lastName%22%3A%22Cristol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandrine%22%2C%22lastName%22%3A%22Arbogast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dalila%22%2C%22lastName%22%3A%22Laoudj-Chenivesse%22%7D%5D%2C%22abstractNote%22%3A%22In%20patients%20with%20facioscapulohumeral%20muscular%20dystrophy%20%28FSHD%29%2C%20a%20rare%20genetic%20neuromuscular%20disease%2C%20reduced%20physical%20performance%20is%20associated%20with%20lower%20blood%20levels%20of%20vitamin%20C%2C%20zinc%2C%20selenium%2C%20and%20increased%20oxidative%20stress%20markers.%20Supplementation%20of%20vitamin%20C%2C%20vitamin%20E%2C%20zinc%2C%20and%20selenium%20improves%20the%20quadriceps%5Cu2019%20physical%20performance.%20Here%2C%20we%20compared%20the%20nutritional%20status%20of%2074%20women%20and%2085%20men%20with%20FSHD.%20Calorie%20intake%20was%20lower%20in%20women%20with%20FSHD%20than%20in%20men.%20Moreover%2C%20we%20assessed%20vitamin%20C%2C%20vitamin%20E%2C%20zinc%2C%20copper%2C%20and%20selenium%20intakes%20in%20diet%20and%20their%20concentrations%20in%20the%20plasma.%20Vitamin%20E%2C%20copper%2C%20and%20zinc%20intake%20were%20lower%20in%20women%20with%20FSHD%20than%20in%20men%2C%20whereas%20plasma%20vitamin%20C%2C%20copper%20levels%2C%20and%20copper%5C%2Fzinc%20ratio%20were%20higher%20in%20women%20with%20FSHD%20than%20in%20men.%20The%20dietary%20intake%20and%20plasma%20concentrations%20of%20the%20studied%20vitamins%20and%20minerals%20were%20not%20correlated%20in%20both%20sexes.%20A%20well-balanced%20and%20varied%20diet%20might%20not%20be%20enough%20in%20patients%20with%20FSHD%20to%20correct%20the%20observed%20vitamin%5C%2Fmineral%20deficiencies.%20A%20low%20energy%20intake%20is%20a%20risk%20factor%20for%20suboptimal%20intake%20of%20proteins%2C%20vitamins%2C%20and%20minerals%20that%20are%20important%20for%20protein%20synthesis%20and%20other%20metabolic%20pathways%20and%20that%20might%20contribute%20to%20progressive%20muscle%20mass%20loss.%20Antioxidant%20supplementation%20and%20higher%20protein%20intake%20seem%20necessary%20to%20confer%20protection%20against%20oxidative%20stress%20and%20skeletal%20muscle%20mass%20loss.%22%2C%22date%22%3A%222023-3-30%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fnu15071673%22%2C%22ISSN%22%3A%222072-6643%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10096775%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-04-22T01%3A06%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22I2582V3P%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hung%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHung%20KC%2C%20Chuang%20MH%2C%20Chen%20JY%2C%20et%20al.%20Impact%20of%20intravenous%20vitamin%20C%20as%20a%20monotherapy%20on%20mortality%20risk%20in%20critically%20ill%20patients%3A%20A%20meta-analysis%20of%20randomized%20controlled%20trials%20with%20trial%20sequential%20analysis.%20%3Ci%3EFront%20Nutr%3C%5C%2Fi%3E.%202023%3B10%3A1094757.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffnut.2023.1094757%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffnut.2023.1094757%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impact%20of%20intravenous%20vitamin%20C%20as%20a%20monotherapy%20on%20mortality%20risk%20in%20critically%20ill%20patients%3A%20A%20meta-analysis%20of%20randomized%20controlled%20trials%20with%20trial%20sequential%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kuo-Chuan%22%2C%22lastName%22%3A%22Hung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min-Hsiang%22%2C%22lastName%22%3A%22Chuang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jen-Yin%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chih-Wei%22%2C%22lastName%22%3A%22Hsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chong-Chi%22%2C%22lastName%22%3A%22Chiu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying-Jen%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chia-Wei%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I-Wen%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cheuk-Kwan%22%2C%22lastName%22%3A%22Sun%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnThis%20meta-analysis%20aimed%20at%20investigating%20the%20pooled%20evidence%20regarding%20the%20effects%20of%20intravenous%20vitamin%20C%20%28IVVC%29%20on%20mortality%20rate%20in%20critically%20ill%20patients.%5Cn%5CnMethods%5CnDatabases%20including%20Medline%2C%20Embase%2C%20and%20Cochrane%20Library%20were%20searched%20from%20inception%20to%20October%2C%202022%20to%20identify%20RCTs.%20The%20primary%20outcome%20was%20the%20risk%20of%20overall%20mortality.%20Subgroup%20analyses%20were%20performed%20based%20on%20IVVC%20dosage%20%28i.e.%2C%20cut-off%20value%3A%20100%20mg%5C%2Fkg%5C%2Fday%20or%2010000%20mg%5C%2Fday%29.%20Trial%20sequential%20analysis%20%28TSA%29%20was%20used%20to%20examine%20the%20robustness%20of%20evidence.%5Cn%5CnResults%5CnA%20total%20of%2012%20trials%20including%201%2C712%20patients%20were%20analyzed.%20Although%20meta-analysis%20demonstrated%20a%20lower%20risk%20of%20mortality%20in%20patients%20with%20IVVC%20treatment%20compared%20to%20those%20without%20%5Brisk%20ratio%20%28RR%29%3A%200.76%2C%2095%25%20CI%3A%200.6%20to%200.97%2C%20p%20%3D%200.02%2C%20I2%20%3D%2036%25%2C%201%2C711%20patients%29%2C%20TSA%20suggested%20the%20need%20for%20more%20studies%20for%20verification.%20Moreover%2C%20subgroup%20analyses%20revealed%20a%20reduced%20mortality%20risk%20associated%20with%20a%20low%20IVVC%20dosage%20%28RR%20%3D%200.72%2C%20p%20%3D%200.03%2C%20546%20patients%29%2C%20while%20no%20beneficial%20effect%20was%20noted%20with%20high%20IVVC%20dosage%20%28RR%20%3D%200.74%2C%20p%20%3D%200.13%2C%20I2%20%3D%2060%25%2C%201%2C165%20patients%29.%20The%20durations%20of%20vasopressor%20%5Bmean%20difference%20%28MD%29%3A%20%5Cu221237.75%20h%2C%20404%20patients%29%20and%20mechanical%20ventilation%20%28MD%3A%20%5Cu221247.29%20h%2C%20388%20patients%29%20use%20were%20shorter%20in%20the%20IVVC%20group%20than%20those%20in%20the%20controls%2C%20while%20there%20was%20no%20significant%20difference%20in%20other%20prognostic%20outcomes%20%28e.g.%2C%20length%20of%20stay%20in%20intensive%20care%20unit%5C%2Fhospital%29%20between%20the%20two%20groups.%5Cn%5CnConclusion%5CnAlthough%20intravenous%20vitamin%20C%20as%20a%20monotherapy%20reduced%20pooled%20mortality%2C%20durations%20of%20vasopressor%20use%20and%20mechanical%20ventilation%2C%20further%20research%20is%20required%20to%20support%20our%20findings%20and%20to%20identify%20the%20optimal%20dosage%20of%20vitamin%20C%20in%20the%20critical%20care%20setting.%5Cn%5CnSystematic%20review%20registration%5Cnhttps%3A%5C%2F%5C%2Fwww.crd.york.ac.uk%5C%2Fprospero%5C%2F%2C%20identifier%20CRD42022371090.%22%2C%22date%22%3A%222023-3-24%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffnut.2023.1094757%22%2C%22ISSN%22%3A%222296-861X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10083893%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-04-22T01%3A04%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22GEHVVMSM%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Marcec%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMarcec%20R%2C%20Posavec%20F%2C%20Likic%20R.%20Vitamin%20C%20utilisation%20in%202020%3A%20have%20we%20bought%20a%20lemon%3F%20%3Ci%3EPostgraduate%20Medical%20Journal%3C%5C%2Fi%3E.%202022%3B98%281163%29%3A651-652.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fpmj-2022-141978%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fpmj-2022-141978%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Vitamin%20C%20utilisation%20in%202020%3A%20have%20we%20bought%20a%20lemon%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Marcec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%22%2C%22lastName%22%3A%22Posavec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Likic%22%7D%5D%2C%22abstractNote%22%3A%22The%20SARS-CoV-2%20pandemic%20drastically%20impacted%20our%20everyday%20lives%20and%20while%20vaccines%20were%20%28and%20some%20still%20are%29%20in%20development%2C%20various%20medicines%20and%20supplements%20were%20suggested%20for%20repurposing%2C%20although%20mostly%20with%20no%20or%20with%20limited%20success.%20Among%20proposed%20over-the-counter%20%28OTC%29%20substances%2C%20vitamin%20C%20%28ascorbic%20acid%29%20stood%20out%20as%20it%20was%20widely%20available%2C%20affordable%2C%20safe%20and%20used%20%28with%20more%20or%20less%20success%29%20in%20the%20past%20for%20the%20prevention%20and%20treatment%20of%20respiratory%20infections%20in%20the%20population.Today%27s%20popularity%20of%20vitamin%20C%20use%20in%20respiratory%20infections%20can%20be%20linked%20to%20the%201970s%20when%20the%20Nobel%20prize%20laureate%20Linus%20Pauling%20popularised%20his%20theory%20that%20vitamin%20C%20can%20be%20used%20prophylactically%20against%20the%20common%20cold%20and%20that%20it%20can%20ameliorate%20its%20symptoms.%20As%20vitamin%20C%20is%20an%20essential%20micronutrient%20and%20antioxidant%20required%20for%20a%20broad%20range%20of%20biological%20processes%2C%20its%20proposed%20beneficial%20effect%20in%20respiratory%20infections%20is%20not%20really%20that%20farfetched.%20Vitamin%20C%20has%20been%20demonstrated%20to%20have%20beneficial%20in%20vitro%20effects%20on%20multiple%20immune%20cells.%20Notably%2C%20it%20can%20accumulate%20in%20phagocytic%20cells%20and%20amplify%20phagocytosis%2C%20chemotaxis%2C%20generation%20of%20reactive%20oxygen%20species%20%28ROS%29%20and%20ultimately%20enhance%20the%20antimicrobial%20activity%20of%20phagocytes.%20The%20role%20of%20vitamin%20C%20in%20lymphocytes%20is%20not%20fully%20explained%2C%20but%20it%20has%20been%20shown%20to%20enhance%20the%20proliferation%20and%20differentiation%20of%20both%20T%20and%20B%20lymphocytes%2C%20possibly%20due%20to%20an%20effect%20on%20gene%20regulation.%20It%20also%20supports%20epithelial%20barrier%20functioning%20and%20assists%20the%20oxidant%20scavenging%20in%20the%20skin%2C%20thus%20potentially%20protecting%20against%20environmental%20oxidative%20stress.1%20Although%20the%20rationale%20behind%20the%20use%20of%20vitamin%20C%20in%20respiratory%20infections%20is%20sound%20and%20it%20is%20well%20known%20that%20vitamin%20C%20deficiency%20results%20in%20impaired%20immunity%20and%20higher%20susceptibility%20to%20infections%2C%20results%20from%20studies%20published%20thus%20far%20do%20not%20support%20the%20prophylactic%20or%20therapeutic%20use%20of%20vitamin%20C%20in%20respiratory%20infections.%22%2C%22date%22%3A%222022-09-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fpmj-2022-141978%22%2C%22ISSN%22%3A%220032-5473%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fpmj-2022-141978%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-04-22T01%3A00%3A49Z%22%7D%7D%2C%7B%22key%22%3A%224IJ2ZF5X%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Coskun%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ECoskun%20N%2C%20Altinay%20M%2C%20Turk%20HS%2C%20et%20al.%20The%20effect%20of%20High-Dose%20Vitamin%20C%20Treatment%20for%20Acute%20Respiratory%20Failure%20Due%20to%20Coronavirus%20Disease%20Pneumonia%20on%20Mortality%20and%20Length%20of%20Intensive%20Care%20Stay%3A%20A%20Retrospective%20Cohort%20Study.%20%3Ci%3ESisli%20Etfal%20Hastan%20Tip%20Bul%3C%5C%2Fi%3E.%202023%3B57%281%29%3A25-32.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14744%5C%2FSEMB.2022.66742%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14744%5C%2FSEMB.2022.66742%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20High-Dose%20Vitamin%20C%20Treatment%20for%20Acute%20Respiratory%20Failure%20Due%20to%20Coronavirus%20Disease%20Pneumonia%20on%20Mortality%20and%20Length%20of%20Intensive%20Care%20Stay%3A%20A%20Retrospective%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nurcan%22%2C%22lastName%22%3A%22Coskun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mustafa%22%2C%22lastName%22%3A%22Altinay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hacer%20Sebnem%22%2C%22lastName%22%3A%22Turk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nebia%22%2C%22lastName%22%3A%22Peker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serkan%22%2C%22lastName%22%3A%22Islamoglu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayse%20Surhan%22%2C%22lastName%22%3A%22Cinar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melis%20Turkel%22%2C%22lastName%22%3A%22Ozkan%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%3A%5CnIn%20our%20study%2C%20we%20aimed%20to%20determine%20the%20effect%20of%20vitamin%20C%20on%20short-term%20mortality%20and%20length%20of%20intensive%20care%20unit%20%28ICU%29%20stay%20in%20patients%20with%20coronavirus%20disease%20%28COVID-19%29%20followed%20up%20in%20the%20ICU.%5Cn%5CnMethods%3A%5CnThe%20patients%20who%20received%20and%20those%20who%20did%20not%20receive%20the%20high-dose%20intravenous%20vitamin%20C%20protocol%20were%20assigned%20to%20the%20treatment%20and%20control%20groups%2C%20respectively.%20The%20primary%20study%20findings%20in%20both%20groups%20were%20length%20of%20ICU%20stay%20and%20short-term%20mortality%2C%20while%20the%20secondary%20findings%20were%20vasopressor%20and%20invasive%20mechanical%20ventilation%20requirements%20and%20change%20in%20sequential%20organ%20failure%20assessment%20score%20from%20the%200%20to%20the%2096th%20hour.%5Cn%5CnResults%3A%5CnThirty-eight%20patients%20were%20included%20in%20the%20treatment%20group%20and%2040%20were%20included%20in%20the%20control%20group.%20The%20mortality%20rates%20were%2044%25%20and%2060%25%20in%20the%20treatment%20and%20control%20groups%2C%20respectively%3B%20however%2C%20the%20difference%20between%20the%20groups%20was%20not%20statistically%20significant%20%28p%3E0.05%29.%20The%20median%20length%20of%20ICU%20stay%20in%20both%20groups%20was%2010%20days%20%28p%3E0.05%29.%20No%20significant%20differences%20in%20the%20invasive%20mechanical%20ventilation%20and%20vasopressor%20requirements%20were%20found%20between%20the%20groups%20%28p%3E0.05%29.%5Cn%5CnConclusion%3A%5CnConsequently%2C%20the%20high-dose%20vitamin%20C%20therapy%20in%20the%20patients%20with%20acute%20respiratory%20failure%20due%20to%20COVID-19%20pneumonia%20did%20not%20reduce%20the%20length%20of%20ICU%20stay%2C%20mortality%2C%20and%20invasive%20mechanical%20ventilation%20and%20vasopressor%20reqirements.%22%2C%22date%22%3A%222023-3-21%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.14744%5C%2FSEMB.2022.66742%22%2C%22ISSN%22%3A%221302-7123%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10098396%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-04-22T00%3A55%3A01Z%22%7D%7D%2C%7B%22key%22%3A%228CL6PJ4U%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hassuna%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHassuna%20NA%2C%20Rabie%20EM%2C%20Mahd%20WKM%2C%20Refaie%20MMM%2C%20Yousef%20RKM%2C%20Abdelraheem%20WM.%20Antibacterial%20effect%20of%20vitamin%20C%20against%20uropathogenic%20E.%20coli%20in%20vitro%20and%20in%20vivo.%20%3Ci%3EBMC%20Microbiol%3C%5C%2Fi%3E.%202023%3B23%281%29%3A112.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12866-023-02856-3%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12866-023-02856-3%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Antibacterial%20effect%20of%20vitamin%20C%20against%20uropathogenic%20E.%20coli%20in%20vitro%20and%20in%20vivo%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noha%20Anwar%22%2C%22lastName%22%3A%22Hassuna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20M.%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22W.%20K.%20M.%22%2C%22lastName%22%3A%22Mahd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marwa%20M.%20M.%22%2C%22lastName%22%3A%22Refaie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rehab%20Kamal%20Mohamed%22%2C%22lastName%22%3A%22Yousef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wedad%20M.%22%2C%22lastName%22%3A%22Abdelraheem%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Resistance%20to%20antibiotics%20has%20increased%20steadily%20over%20time%2C%20thus%20there%20is%20a%20pressing%20need%20for%20safer%20alternatives%20to%20antibiotics.%20Current%20study%20aims%20to%20evaluate%20the%20influence%20of%20vitamin%20C%20as%20an%20antibacterial%20and%20anti-biofilm%20agent%20against%20uropathogenic%20E.%20coli%20%28UPEC%29%20strains.%20The%20expression%20of%20beta-lactamases%20and%20biofilm%20encoding%20genes%20among%20E.%20coli%20isolates%20before%20and%20after%20treating%20the%20isolates%20with%20sub%20MIC%20of%20vitamin%20C%20was%20analyzed%20by%20Real-time%20PCR.%20The%20in%20vivo%20assessment%20of%20the%20antibacterial%20and%20anti-biofilm%20effects%20of%20vitamin%20C%20against%20uropathogenic%20E.%20coli%20strains%20was%20done%20using%20a%20urinary%20tract%20infection%20%28UTI%29%20rat%20model.%5CnRESULTS%3A%20The%20effective%20concentration%20of%20vitamin%20C%20that%20could%20inhibit%20the%20growth%20of%20most%20study%20isolates%20%2870%25%29%20was%201.25%5Cu00a0mg%5C%2Fml.%20Vitamin%20C%20showed%20a%20synergistic%20effect%20with%20most%20of%20the%20studied%20antibiotics%3B%20no%20antagonistic%20effect%20was%20detected%20at%20all.%20Vitamin%20C%20showed%20an%20excellent%20anti-biofilm%20effect%20against%20studied%20isolates%2C%20where%2043%20biofilm-producing%20isolates%20were%20converted%20to%20non-biofilm%20at%20a%20concentration%20of%200.312%5Cu00a0mg%5C%2Fml.%20The%20expression%20levels%20of%20most%20studied%20genes%20were%20down-regulated%20after%20treatment%20of%20E.%20coli%20isolates%20with%20vitamin%20C.%20In%20vivo%20assessment%20of%20vitamin%20C%20in%20treating%20UTIs%20showed%20that%20vitamin%20C%20has%20a%20rapid%20curative%20effect%20as%20the%20comparable%20antibiotic.%20Administration%20of%20both%20vitamin%20C%20and%20nitrofurantoin%20at%20a%20lower%20dose%20for%20treatment%20of%20UTI%20in%20rats%20had%20a%20better%20effect.%5CnCONCLUSION%3A%20Vitamin%20C%20as%20an%20antibacterial%20and%20anti-biofilm%20agent%20either%20alone%20or%20in%20combination%20with%20antibiotics%20could%20markedly%20improve%20UTI%20in%20experimental%20rats.%22%2C%22date%22%3A%222023-04-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12866-023-02856-3%22%2C%22ISSN%22%3A%221471-2180%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-04-22T00%3A53%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22DSBGPXPB%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Volek%20et%20al.%22%2C%22parsedDate%22%3A%222021-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EVolek%20JS%2C%20Phinney%20SD%2C%20Krauss%20RM%2C%20et%20al.%20Alternative%20Dietary%20Patterns%20for%20Americans%3A%20Low-Carbohydrate%20Diets.%20%3Ci%3ENutrients%3C%5C%2Fi%3E.%202021%3B13%2810%29%3A3299.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fnu13103299%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fnu13103299%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Alternative%20Dietary%20Patterns%20for%20Americans%3A%20Low-Carbohydrate%20Diets%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeff%20S.%22%2C%22lastName%22%3A%22Volek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20D.%22%2C%22lastName%22%3A%22Phinney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%20M.%22%2C%22lastName%22%3A%22Krauss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%20R.%22%2C%22lastName%22%3A%22Saslow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Gower%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20S.%22%2C%22lastName%22%3A%22Yancy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janet%20C.%22%2C%22lastName%22%3A%22King%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederick%20M.%22%2C%22lastName%22%3A%22Hecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Teicholz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruce%20R.%22%2C%22lastName%22%3A%22Bistrian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Osama%22%2C%22lastName%22%3A%22Hamdy%22%7D%5D%2C%22abstractNote%22%3A%22The%20decades-long%20dietary%20experiment%20embodied%20in%20the%20Dietary%20Guidelines%20for%20Americans%20%28DGA%29%20focused%20on%20limiting%20fat%2C%20especially%20saturated%20fat%2C%20and%20higher%20carbohydrate%20intake%20has%20coincided%20with%20rapidly%20escalating%20epidemics%20of%20obesity%20and%20type%202%20diabetes%20%28T2D%29%20that%20are%20contributing%20to%20the%20progression%20of%20cardiovascular%20disease%20%28CVD%29%20and%20other%20diet-related%20chronic%20diseases.%20Moreover%2C%20the%20lack%20of%20flexibility%20in%20the%20DGA%20as%20it%20pertains%20to%20low%20carbohydrate%20approaches%20does%20not%20align%20with%20the%20contemporary%20trend%20toward%20precision%20nutrition.%20We%20argue%20that%20personalizing%20the%20level%20of%20dietary%20carbohydrate%20should%20be%20a%20high%20priority%20based%20on%20evidence%20that%20Americans%20have%20a%20wide%20spectrum%20of%20metabolic%20variability%20in%20their%20tolerance%20to%20high%20carbohydrate%20loads.%20Obesity%2C%20metabolic%20syndrome%2C%20and%20T2D%20are%20conditions%20strongly%20associated%20with%20insulin%20resistance%2C%20a%20condition%20exacerbated%20by%20increased%20dietary%20carbohydrate%20and%20improved%20by%20restricting%20carbohydrate.%20Low-carbohydrate%20diets%20are%20grounded%20across%20the%20time-span%20of%20human%20evolution%2C%20have%20well-established%20biochemical%20principles%2C%20and%20are%20now%20supported%20by%20multiple%20clinical%20trials%20in%20humans%20that%20demonstrate%20consistent%20improvements%20in%20multiple%20established%20risk%20factors%20associated%20with%20insulin%20resistance%20and%20cardiovascular%20disease.%20The%20American%20Diabetes%20Association%20%28ADA%29%20recently%20recognized%20a%20low%20carbohydrate%20eating%20pattern%20as%20an%20effective%20approach%20for%20patients%20with%20diabetes.%20Despite%20this%20evidence%20base%2C%20low-carbohydrate%20diets%20are%20not%20reflected%20in%20the%20DGA.%20As%20the%20DGA%20Dietary%20Patterns%20have%20not%20been%20demonstrated%20to%20be%20universally%20effective%20in%20addressing%20the%20needs%20of%20many%20Americans%20and%20recognizing%20the%20lack%20of%20widely%20available%20treatments%20for%20obesity%2C%20metabolic%20syndrome%2C%20and%20T2D%20that%20are%20safe%2C%20effective%2C%20and%20sustainable%2C%20the%20argument%20for%20an%20alternative%2C%20low-carbohydrate%20Dietary%20Pattern%20is%20all%20the%20more%20compelling.%22%2C%22date%22%3A%222021%5C%2F10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fnu13103299%22%2C%22ISSN%22%3A%222072-6643%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2072-6643%5C%2F13%5C%2F10%5C%2F3299%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-04-19T01%3A58%3A58Z%22%7D%7D%2C%7B%22key%22%3A%224QLGEAA7%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sampson%22%2C%22parsedDate%22%3A%222016-10-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESampson%20HA.%20Food%20allergy%3A%20Past%2C%20present%20and%20future.%20%3Ci%3EAllergology%20International%3C%5C%2Fi%3E.%202016%3B65%284%29%3A363-369.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.alit.2016.08.006%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.alit.2016.08.006%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Food%20allergy%3A%20Past%2C%20present%20and%20future%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugh%20A.%22%2C%22lastName%22%3A%22Sampson%22%7D%5D%2C%22abstractNote%22%3A%22Hippocrates%20is%20often%20credited%20with%20first%20recognizing%20that%20food%20could%20be%20responsible%20for%20adverse%20symptoms%20and%20even%20death%20in%20some%20individuals%2C%20but%20it%20was%20not%20until%20the%20seminal%20observations%20by%20Prausnitz%20that%20the%20investigation%20of%20food%20allergy%20was%20viewed%20on%20a%20more%20scientific%20basis.%20In%20the%20first%20half%20of%20the%2020th%20century%2C%20there%20were%20periodic%20reports%20in%20the%20medical%20literature%20describing%20various%20food%20allergic%20reactions.%20In%20the%20mid-%20to%20late-%201970%27s%2C%20the%20studies%20of%20Charles%20May%20and%20colleagues%20began%20to%20penetrate%20the%20medical%20world%27s%20skepticism%20about%20the%20relevance%20of%20food%20allergy%20and%20how%20to%20diagnose%20it%2C%20since%20standard%20skin%20testing%20was%20known%20to%20correlate%20poorly%20with%20clinical%20symptoms.%20With%20May%27s%20introduction%20of%20the%20double-blind%20placebo-controlled%20oral%20food%20challenge%2C%20the%20study%20of%20food%20allergy%20became%20evidence-based%20and%20exponential%20strides%20have%20been%20made%20over%20the%20past%20four%20decades%20in%20the%20study%20of%20basic%20immunopathogenic%20mechanisms%20and%20natural%20history%2C%20and%20the%20diagnosis%20and%20management%20of%20food%20allergies.%20Today%20IgE-%20and%20non-IgE-mediated%20food%20allergic%20disorders%20are%20well%20characterized%20and%20efforts%20to%20treat%20these%20allergies%20by%20various%20immunotherapeutic%20strategies%20are%20well%20under%20way.%22%2C%22date%22%3A%222016-10-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.alit.2016.08.006%22%2C%22ISSN%22%3A%221323-8930%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1323893016301137%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-08T17%3A49%3A10Z%22%7D%7D%2C%7B%22key%22%3A%228KNQUT8S%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chen%20et%20al.%22%2C%22parsedDate%22%3A%222018-07-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EChen%20H%2C%20McGowan%20EM%2C%20Ren%20N%2C%20et%20al.%20Nattokinase%3A%20A%20Promising%20Alternative%20in%20Prevention%20and%20Treatment%20of%20Cardiovascular%20Diseases.%20%3Ci%3EBiomark%20Insights%3C%5C%2Fi%3E.%202018%3B13%3A1177271918785130.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F1177271918785130%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F1177271918785130%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nattokinase%3A%20A%20Promising%20Alternative%20in%20Prevention%20and%20Treatment%20of%20Cardiovascular%20Diseases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongjie%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eileen%20M%22%2C%22lastName%22%3A%22McGowan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Lal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Najah%22%2C%22lastName%22%3A%22Nassif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatima%22%2C%22lastName%22%3A%22Shad-Kaneez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xianqin%22%2C%22lastName%22%3A%22Qu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yiguang%22%2C%22lastName%22%3A%22Lin%22%7D%5D%2C%22abstractNote%22%3A%22Cardiovascular%20disease%20%28CVD%29%20is%20the%20leading%20cause%20of%20death%20in%20the%20world%20and%20our%20approach%20to%20the%20control%20and%20management%20of%20CVD%20mortality%20is%20limited.%20Nattokinase%20%28NK%29%2C%20the%20most%20active%20ingredient%20of%20natto%2C%20possesses%20a%20variety%20of%20favourable%20cardiovascular%20effects%20and%20the%20consumption%20of%20Natto%20has%20been%20linked%20to%20a%20reduction%20in%20CVD%20mortality.%20Recent%20research%20has%20demonstrated%20that%20NK%20has%20potent%20fibrinolytic%20activity%2C%20antihypertensive%2C%20anti-atherosclerotic%2C%20and%20lipid-lowering%2C%20antiplatelet%2C%20and%20neuroprotective%20effects.%20This%20review%20covers%20the%20major%20pharmacologic%20effects%20of%20NK%20with%20a%20focus%20on%20its%20clinical%20relevance%20to%20CVD.%20It%20outlines%20the%20advantages%20of%20NK%20and%20the%20outstanding%20issues%20pertaining%20to%20NK%20pharmacokinetics.%20Available%20evidence%20suggests%20that%20NK%20is%20a%20unique%20natural%20compound%20that%20possesses%20several%20key%20cardiovascular%20beneficial%20effects%20for%20patients%20with%20CVD%20and%20is%20therefore%20an%20ideal%20drug%20candidate%20for%20the%20prevention%20and%20treatment%20of%20CVD.%20Nattokinase%20is%20a%20promising%20alternative%20in%20the%20management%20of%20CVD.%22%2C%22date%22%3A%222018-7-05%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1177%5C%2F1177271918785130%22%2C%22ISSN%22%3A%221177-2719%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC6043915%5C%2F%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-04-01T19%3A26%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22MEVG5WR8%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liang%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELiang%20B%2C%20Su%20J%2C%20Shao%20H%2C%20Chen%20H%2C%20Xie%20B.%20The%20outcome%20of%20IV%20vitamin%20C%20therapy%20in%20patients%20with%20sepsis%20or%20septic%20shock%3A%20a%20meta-analysis%20of%20randomized%20controlled%20trials.%20%3Ci%3ECrit%20Care%3C%5C%2Fi%3E.%202023%3B27%3A109.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13054-023-04392-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13054-023-04392-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20outcome%20of%20IV%20vitamin%20C%20therapy%20in%20patients%20with%20sepsis%20or%20septic%20shock%3A%20a%20meta-analysis%20of%20randomized%20controlled%20trials%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baofang%22%2C%22lastName%22%3A%22Liang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jianwei%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanquan%22%2C%22lastName%22%3A%22Shao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huiying%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baocheng%22%2C%22lastName%22%3A%22Xie%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnTo%20update%20a%20meta-analysis%20of%20randomized%20controlled%20trials%20%28RCTs%29%20and%20further%20explore%20the%20outcome%20of%20IV%20vitamin%20C%20%28IVVC%29%20administration%20in%20sepsis%20or%20septic%20shock%20patients.%5Cn%5CnMethods%5CnThis%20study%20is%20a%20meta-analysis%20of%20RCTs.%20The%20RCTs%20of%20vitamin%20C%20therapy%20in%20sepsis%20or%20septic%20shock%20were%20searched%20in%20PubMed%2C%20EMBASE%20and%20Clinical%20Trials.gov%20from%20inception%20to%20January%2016%2C%202023.%20We%20registered%20the%20protocol%20with%20PROSPERO%20%28CRD42022354875%29.%20The%20primary%20outcome%20was%20delta%20Sequential%20Organ%20Failure%20Assessment%20%28SOFA%29%20score%20at%2072%5Cu201396%5Cu00a0h.%20Two%20reviewers%20independently%20assessed%20RCTs%20according%20to%20eligibility%20criteria%3A%20%281%29%20study%20type%3A%20RCT%3B%20%282%29%20patient%20population%3A%20patients%5Cu2009%5Cu2265%5Cu200918%5Cu00a0years%20with%20sepsis%20or%20septic%20shock%3B%20%283%29%20intervention%3A%20IVVC%20at%20any%20doses%20as%20monotherapy%20or%20combined%20with%20thiamine%20or%20and%20hydrocortisone%20compared%20with%20standard%20of%20care%2C%20no%20intervention%20or%20placebo%20%28defined%20as%20control%20group%29%3B%20%284%29%20the%20RCT%20described%20short-term%20mortality%20or%20SOFA%20score.%20Then%2C%20two%20authors%20independently%20extracted%20related%20information%20from%20RCTs.%5Cn%5CnResults%5CnEighteen%20RCTs%20%28n%5Cu2009%3D%5Cu20093364%20patients%29%20were%20identified%20in%20this%20meta-analysis.%20There%20were%20significant%20effects%20in%20the%20delta%20SOFA%20score%20from%20baseline%20to%2072%5Cu201396%5Cu00a0h%20%28MD%2C%20%5Cu2212%5Cu20090.62%3B%2095%25%20CI%2C%20%5Cu2212%5Cu20091.00%20to%20%5Cu2212%5Cu20090.25%3B%20p%5Cu2009%3D%5Cu20090.001%29%20and%20the%20duration%20of%20vasopressor%20use%20%28MD%2C%20%5Cu2212%5Cu200915.07%3B%2095%25%20CI%2C%20%5Cu2212%5Cu200921.59%20to%20%5Cu2212%5Cu20098.55%3B%20p%5Cu2009%3C%5Cu20090.00001%29%20with%20IVVC%20therapy.%20Treatment%20with%20IVVC%20was%20not%20shown%20to%20improve%20short-term%20mortality%20%28OR%2C%200.89%3B%2095%25%20CI%2C%200.77%20to%201.04%3B%20p%5Cu2009%3D%5Cu20090.14%29%3B%20nevertheless%2C%20dose%20at%2025%5Cu2013100%5Cu00a0mg%5C%2Fkg%5C%2Fd%20subgroup%20associated%20with%20a%20significant%20reduction%20in%20short-term%20mortality%20%28OR%2C%200.80%3B%2095%25%20CI%2C%200.65%20to%200.97%3B%20p%5Cu2009%3D%5Cu20090.03%29.%20An%20increase%20adverse%20event%20was%20observed%20in%20IVVC%20therapy%20%28OR%2C%201.98%3B%2095%25%20CI%2C%201.06%20to%203.68%3B%20p%5Cu2009%3D%5Cu20090.03%29.%5Cn%5CnConclusion%5CnIn%20this%20meta-analysis%2C%20IVVC%20in%20sepsis%20or%20septic%20shock%20patients%20significantly%20improved%20delta%20SOFA%20score%20and%20reduced%20the%20duration%20of%20vasopressor%20use%2C%20whereas%20it%20was%20not%20associated%20with%20reduction%20in%20short-term%20mortality%20and%20had%20higher%20adverse%20events.%5Cn%5CnSupplementary%20Information%5CnThe%20online%20version%20contains%20supplementary%20material%20available%20at%2010.1186%5C%2Fs13054-023-04392-y.%22%2C%22date%22%3A%222023-3-13%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13054-023-04392-y%22%2C%22ISSN%22%3A%221364-8535%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10012592%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-03-19T23%3A27%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22Y5XZPE9V%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lbban%20et%20al.%22%2C%22parsedDate%22%3A%222023-05-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELbban%20E%2C%20Ashor%20A%2C%20Shannon%20OM%2C%20Idris%20I%2C%20Siervo%20M.%20Is%20vitamin%20C%20a%20booster%20of%20the%20effects%20of%20dietary%20nitrate%20on%20endothelial%20function%3F%20Physiologic%20rationale%20and%20implications%20for%20research.%20%3Ci%3ENutrition%3C%5C%2Fi%3E.%202023%3B109%3A111995.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.nut.2023.111995%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.nut.2023.111995%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Is%20vitamin%20C%20a%20booster%20of%20the%20effects%20of%20dietary%20nitrate%20on%20endothelial%20function%3F%20Physiologic%20rationale%20and%20implications%20for%20research%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eazaz%22%2C%22lastName%22%3A%22Lbban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ammar%22%2C%22lastName%22%3A%22Ashor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%20M%22%2C%22lastName%22%3A%22Shannon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iskandar%22%2C%22lastName%22%3A%22Idris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mario%22%2C%22lastName%22%3A%22Siervo%22%7D%5D%2C%22abstractNote%22%3A%22Endothelial%20dysfunction%20%28ED%29%20is%20an%20early%20marker%20of%20vascular%20damage%20linked%20to%20the%20loss%20of%20integrity%20of%20the%20endothelial%20lining%20and%20represents%20a%20key%20step%20in%20the%20pathogenesis%20of%20atherosclerosis%20and%20cardiovascular%20diseases%20%28CVDs%29.%20ED%20may%20be%20reversible%2C%20hence%20the%20development%20and%20testing%20of%20effective%20early%20interventions%20could%20be%20beneficial%20for%20the%20prevention%20and%20treatment%20of%20CVDs.%20Recent%20studies%20have%20demonstrated%20that%20the%20consumption%20of%20dietary%20nitrate%20%28NO3%5Cu2013%29%2C%20an%20inorganic%20anion%20that%20serves%20as%20a%20substrate%20for%20the%20gas%20transmitter%20nitric%20oxide%20%28NO%29%2C%20can%20lower%20blood%20pressure%2C%20improve%20endothelial%20function%20and%2C%20in%20observational%20studies%2C%20reduce%20the%20risk%20for%20CVD.%20We%20hypothesize%20that%20the%20co-consumption%20of%20NO3%5Cu2013%20with%20vitamin%20C%2C%20which%20is%20a%20potent%20antioxidant%2C%20could%20enhance%20the%20%5Cu201cyield%5Cu201d%20of%20NO%20produced%20from%20a%20given%20NO3%5Cu2013%20dose%20by%5Cu2022Promoting%20a%20more%20efficient%20conversion%20between%20nitrite%20%28NO2%5Cu2013%29%20and%20NO%2C%5Cu2022Potentiating%20the%20l-arginine%20pathway%20to%20increase%20NO%20generation%2C%20and%5Cu2022Attenuating%20NO%20degradation.This%20could%20translate%20into%20greater%20NO-dependent%20effects%20on%20endothelial%20function%20%28EF%29%20and%20overall%20vascular%20health%20%28than%20may%20be%20experienced%20with%20NO3%5Cu2013%20supplementation%20alone%29.%20This%20review%20presents%20evidence%20to%20suggest%20that%20the%20combination%20of%20vitamin%20C%20and%20dietary%20nitrate%20could%20represent%20a%20promising%20and%20effective%20approach%20to%20improve%20EF%20and%20reduce%20CVD%20risk%2C%20and%20discuss%20opportunities%20for%20future%20research.%22%2C%22date%22%3A%222023-05-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.nut.2023.111995%22%2C%22ISSN%22%3A%220899-9007%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0899900723000254%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-03-19T23%3A16%3A05Z%22%7D%7D%2C%7B%22key%22%3A%226JSUTLEC%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jefferson%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJefferson%20T%2C%20Dooley%20L%2C%20Ferroni%20E%2C%20et%20al.%20Physical%20interventions%20to%20interrupt%20or%20reduce%20the%20spread%20of%20respiratory%20viruses.%20Cochrane%20Acute%20Respiratory%20Infections%20Group%2C%20ed.%20%3Ci%3ECochrane%20Database%20of%20Systematic%20Reviews%3C%5C%2Fi%3E.%202023%3B2023%281%29.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F14651858.CD006207.pub6%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F14651858.CD006207.pub6%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Physical%20interventions%20to%20interrupt%20or%20reduce%20the%20spread%20of%20respiratory%20viruses%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22Cochrane%20Acute%20Respiratory%20Infections%20Group%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Jefferson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liz%22%2C%22lastName%22%3A%22Dooley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliana%22%2C%22lastName%22%3A%22Ferroni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lubna%20A%22%2C%22lastName%22%3A%22Al-Ansary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mieke%20L%22%2C%22lastName%22%3A%22Van%20Driel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ghada%20A%22%2C%22lastName%22%3A%22Bawazeer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20A%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tammy%20C%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elaine%20M%22%2C%22lastName%22%3A%22Beller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20P%22%2C%22lastName%22%3A%22Glasziou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20M%22%2C%22lastName%22%3A%22Conly%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-01-30%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2F14651858.CD006207.pub6%22%2C%22ISSN%22%3A%2214651858%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdoi.wiley.com%5C%2F10.1002%5C%2F14651858.CD006207.pub6%22%2C%22collections%22%3A%5B%22432N228B%22%5D%2C%22dateModified%22%3A%222023-03-18T13%3A57%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22KYQZD59D%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kearns%20et%20al.%22%2C%22parsedDate%22%3A%222016-11-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKearns%20CE%2C%20Schmidt%20LA%2C%20Glantz%20SA.%20Sugar%20Industry%20and%20Coronary%20Heart%20Disease%20Research%3A%20A%20Historical%20Analysis%20of%20Internal%20Industry%20Documents.%20%3Ci%3EJAMA%20Internal%20Medicine%3C%5C%2Fi%3E.%202016%3B176%2811%29%3A1680-1685.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamainternmed.2016.5394%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamainternmed.2016.5394%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sugar%20Industry%20and%20Coronary%20Heart%20Disease%20Research%3A%20A%20Historical%20Analysis%20of%20Internal%20Industry%20Documents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristin%20E.%22%2C%22lastName%22%3A%22Kearns%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%20A.%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stanton%20A.%22%2C%22lastName%22%3A%22Glantz%22%7D%5D%2C%22abstractNote%22%3A%22Early%20warning%20signals%20of%20the%20coronary%20heart%20disease%20%28CHD%29%20risk%20of%20sugar%20%28sucrose%29%20emerged%20in%20the%201950s.%20We%20examined%20Sugar%20Research%20Foundation%20%28SRF%29%20internal%20documents%2C%20historical%20reports%2C%20and%20statements%20relevant%20to%20early%20debates%20about%20the%20dietary%20causes%20of%20CHD%20and%20assembled%20findings%20chronologically%20into%20a%20narrative%20case%20study.%20The%20SRF%20sponsored%20its%20first%20CHD%20research%20project%20in%201965%2C%20a%20literature%20review%20published%20in%20the%20New%20England%20Journal%20of%20Medicine%2C%20which%20singled%20out%20fat%20and%20cholesterol%20as%20the%20dietary%20causes%20of%20CHD%20and%20downplayed%20evidence%20that%20sucrose%20consumption%20was%20also%20a%20risk%20factor.%20The%20SRF%20set%20the%20review%5Cu2019s%20objective%2C%20contributed%20articles%20for%20inclusion%2C%20and%20received%20drafts.%20The%20SRF%5Cu2019s%20funding%20and%20role%20was%20not%20disclosed.%20Together%20with%20other%20recent%20analyses%20of%20sugar%20industry%20documents%2C%20our%20findings%20suggest%20the%20industry%20sponsored%20a%20research%20program%20in%20the%201960s%20and%201970s%20that%20successfully%20cast%20doubt%20about%20the%20hazards%20of%20sucrose%20while%20promoting%20fat%20as%20the%20dietary%20culprit%20in%20CHD.%20Policymaking%20committees%20should%20consider%20giving%20less%20weight%20to%20food%20industry%5Cu2013funded%20studies%20and%20include%20mechanistic%20and%20animal%20studies%20as%20well%20as%20studies%20appraising%20the%20effect%20of%20added%20sugars%20on%20multiple%20CHD%20biomarkers%20and%20disease%20development.%22%2C%22date%22%3A%222016-11-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1001%5C%2Fjamainternmed.2016.5394%22%2C%22ISSN%22%3A%222168-6106%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamainternmed.2016.5394%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-03-18T13%3A33%3A24Z%22%7D%7D%2C%7B%22key%22%3A%229EJ7N9Q8%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Feinman%20et%20al.%22%2C%22parsedDate%22%3A%222015-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EFeinman%20RD%2C%20Pogozelski%20WK%2C%20Astrup%20A%2C%20et%20al.%20Dietary%20carbohydrate%20restriction%20as%20the%20first%20approach%20in%20diabetes%20management%3A%20Critical%20review%20and%20evidence%20base.%20%3Ci%3ENutrition%3C%5C%2Fi%3E.%202015%3B31%281%29%3A1-13.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.nut.2014.06.011%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.nut.2014.06.011%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Dietary%20carbohydrate%20restriction%20as%20the%20first%20approach%20in%20diabetes%20management%3A%20Critical%20review%20and%20evidence%20base%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20D.%22%2C%22lastName%22%3A%22Feinman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wendy%20K.%22%2C%22lastName%22%3A%22Pogozelski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arne%22%2C%22lastName%22%3A%22Astrup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20K.%22%2C%22lastName%22%3A%22Bernstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eugene%20J.%22%2C%22lastName%22%3A%22Fine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20C.%22%2C%22lastName%22%3A%22Westman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%22%2C%22lastName%22%3A%22Accurso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lynda%22%2C%22lastName%22%3A%22Frassetto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%20A.%22%2C%22lastName%22%3A%22Gower%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samy%20I.%22%2C%22lastName%22%3A%22McFarlane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rgen%20Vesti%22%2C%22lastName%22%3A%22Nielsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thure%22%2C%22lastName%22%3A%22Krarup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Saslow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl%20S.%22%2C%22lastName%22%3A%22Roth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary%20C.%22%2C%22lastName%22%3A%22Vernon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeff%20S.%22%2C%22lastName%22%3A%22Volek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilbert%20B.%22%2C%22lastName%22%3A%22Wilshire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Dahlqvist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralf%22%2C%22lastName%22%3A%22Sundberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ann%22%2C%22lastName%22%3A%22Childers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharine%22%2C%22lastName%22%3A%22Morrison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anssi%20H.%22%2C%22lastName%22%3A%22Manninen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hussain%20M.%22%2C%22lastName%22%3A%22Dashti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20J.%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jay%22%2C%22lastName%22%3A%22Wortman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolai%22%2C%22lastName%22%3A%22Worm%22%7D%5D%2C%22abstractNote%22%3A%22The%20inability%20of%20current%20recommendations%20to%20control%20the%20epidemic%20of%20diabetes%2C%20the%20specific%20failure%20of%20the%20prevailing%20low-fat%20diets%20to%20improve%20obesity%2C%20cardiovascular%20risk%2C%20or%20general%20health%20and%20the%20persistent%20reports%20of%20some%20serious%20side%20effects%20of%20commonly%20prescribed%20diabetic%20medications%2C%20in%20combination%20with%20the%20continued%20success%20of%20low-carbohydrate%20diets%20in%20the%20treatment%20of%20diabetes%20and%20metabolic%20syndrome%20without%20significant%20side%20effects%2C%20point%20to%20the%20need%20for%20a%20reappraisal%20of%20dietary%20guidelines.%20The%20benefits%20of%20carbohydrate%20restriction%20in%20diabetes%20are%20immediate%20and%20well%20documented.%20Concerns%20about%20the%20efficacy%20and%20safety%20are%20long%20term%20and%20conjectural%20rather%20than%20data%20driven.%20Dietary%20carbohydrate%20restriction%20reliably%20reduces%20high%20blood%20glucose%2C%20does%20not%20require%20weight%20loss%20%28although%20is%20still%20best%20for%20weight%20loss%29%2C%20and%20leads%20to%20the%20reduction%20or%20elimination%20of%20medication.%20It%20has%20never%20shown%20side%20effects%20comparable%20with%20those%20seen%20in%20many%20drugs.%20Here%20we%20present%2012%20points%20of%20evidence%20supporting%20the%20use%20of%20low-carbohydrate%20diets%20as%20the%20first%20approach%20to%20treating%20type%202%20diabetes%20and%20as%20the%20most%20effective%20adjunct%20to%20pharmacology%20in%20type%201.%20They%20represent%20the%20best-documented%2C%20least%20controversial%20results.%20The%20insistence%20on%20long-term%20randomized%20controlled%20trials%20as%20the%20only%20kind%20of%20data%20that%20will%20be%20accepted%20is%20without%20precedent%20in%20science.%20The%20seriousness%20of%20diabetes%20requires%20that%20we%20evaluate%20all%20of%20the%20evidence%20that%20is%20available.%20The%2012%20points%20are%20sufficiently%20compelling%20that%20we%20feel%20that%20the%20burden%20of%20proof%20rests%20with%20those%20who%20are%20opposed.%22%2C%22date%22%3A%222015-01-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.nut.2014.06.011%22%2C%22ISSN%22%3A%220899-9007%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0899900714003323%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222023-03-15T18%3A31%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22PHBFVPKT%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Labbani-Motlagh%20et%20al.%22%2C%22parsedDate%22%3A%222022-12-14%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELabbani-Motlagh%20Z%2C%20Amini%20S%2C%20Aliannejad%20R%2C%20et%20al.%20High-dose%20Intravenous%20Vitamin%20C%20in%20Early%20Stages%20of%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20Infection%3A%20A%20Double-blind%2C%20Randomized%2C%20Controlled%20Clinical%20Trial.%20%3Ci%3EJ%20Res%20Pharm%20Pract%3C%5C%2Fi%3E.%202022%3B11%282%29%3A64-72.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4103%5C%2Fjrpp.jrpp_30_22%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4103%5C%2Fjrpp.jrpp_30_22%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High-dose%20Intravenous%20Vitamin%20C%20in%20Early%20Stages%20of%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20Infection%3A%20A%20Double-blind%2C%20Randomized%2C%20Controlled%20Clinical%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zohre%22%2C%22lastName%22%3A%22Labbani-Motlagh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shahideh%22%2C%22lastName%22%3A%22Amini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rasoul%22%2C%22lastName%22%3A%22Aliannejad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anahita%22%2C%22lastName%22%3A%22Sadeghi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gita%22%2C%22lastName%22%3A%22Shafiee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramin%22%2C%22lastName%22%3A%22Heshmat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamadreza%22%2C%22lastName%22%3A%22Jafary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mona%22%2C%22lastName%22%3A%22Talaschian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maryam%22%2C%22lastName%22%3A%22Akhtari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmadreza%22%2C%22lastName%22%3A%22Jamshidi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahdi%22%2C%22lastName%22%3A%22Mahmoudi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kourosh%22%2C%22lastName%22%3A%22Sadeghi%22%7D%5D%2C%22abstractNote%22%3A%22Objective%3A%5CnBased%20on%20previous%20studies%20in%20the%20sepsis%20population%2C%20Vitamin%20C%20could%20prevent%20injuries%20when%20administered%20in%20high%20doses%20and%20before%20the%20damage%20is%20established.%20This%20study%20aimed%20to%20evaluate%20the%20protective%20potentials%20of%20high-dose%20Vitamin%20C%20in%20the%20progression%20of%20coronavirus%20disease%202019%20%28COVID-19%29.%5Cn%5CnMethods%3A%5CnA%20double-blind%2C%20placebo-controlled%20clinical%20trial%20was%20conducted.%20Patients%20with%20moderate-to-severe%20disease%20severity%20based%20on%20the%20World%20Health%20Organization%20definition%20were%20enrolled%20and%20received%2012%20g%5C%2Fd%20Vitamin%20C%20%28high-dose%20intravenous%20Vitamin%20C%20%5BHDIVC%5D%29%20or%20placebo%20for%204%20days.%20Sequential%20Organ%20Failure%20Assessment%20%28SOFA%29%20score%20as%20a%20primary%20outcome%2C%20National%20Early%20Warning%20Score%2C%20Ordinal%20Scale%20of%20Clinical%20Improvement%2C%20and%20cytokine%20storm%20biomarkers%20were%20recorded%20on%20days%200%2C%203%2C%20and%205.%20Survival%20was%20also%20assessed%20on%20day%2028%20after%20enrollment.%5Cn%5CnFindings%3A%5CnSeventy-four%20patients%20%2837%20patients%20in%20each%20group%29%20were%20enrolled%20from%20April%205%2C%202020%2C%20to%20November%2019%2C%202020%2C%20and%20all%20patients%20completed%20follow-up.%20A%20lower%20increase%20in%20SOFA%20score%20during%20the%20first%203%20days%20of%20treatment%20%28%2B0.026%20vs.%20%2B0.204%29%20and%20a%20higher%20decrease%20in%20this%20parameter%20in%20the%20last%202%20days%20%28%5Cu22120.462%20vs.%20%5Cu22120.036%29%20were%20observed%20in%20the%20treatment%20group.%20However%2C%20these%20differences%20did%20not%20reach%20a%20significance%20level%20%28P%20%3D%200.57%20and%200.12%2C%20respectively%29.%20Other%20indices%20of%20clinical%20and%20biological%20improvement%2C%20length%20of%20hospitalization%2C%20and%20intensive%20care%20unit%20admission%20days%20were%20the%20same%20between%20the%20two%20groups.%20Treatment%20did%20not%20affect%20the%2028-day%20mortality.%5Cn%5CnConclusion%3A%5CnAmong%20patients%20with%20moderate-to-severe%20disease%20of%20COVID-19%2C%20the%20use%20of%20HDIVC%20plus%20standard%20care%20resulted%20in%20no%20significant%20difference%20in%20SOFA%20score%20or%2028-day%20mortality%20compared%20to%20the%20standard%20care%20alone.%22%2C%22date%22%3A%222022-12-14%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.4103%5C%2Fjrpp.jrpp_30_22%22%2C%22ISSN%22%3A%222319-9644%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9926917%5C%2F%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-02-20T22%3A57%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22FDMRHCUQ%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Johannesen%20et%20al.%22%2C%22parsedDate%22%3A%222020-12-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJohannesen%20CDL%2C%20Langsted%20A%2C%20Mortensen%20MB%2C%20Nordestgaard%20BG.%20Association%20between%20low%20density%20lipoprotein%20and%20all%20cause%20and%20cause%20specific%20mortality%20in%20Denmark%3A%20prospective%20cohort%20study.%20%3Ci%3EBMJ%3C%5C%2Fi%3E.%202020%3B371%3Am4266.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmj.m4266%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmj.m4266%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20low%20density%20lipoprotein%20and%20all%20cause%20and%20cause%20specific%20mortality%20in%20Denmark%3A%20prospective%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camilla%20Ditlev%20Lindhardt%22%2C%22lastName%22%3A%22Johannesen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Langsted%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20B%5Cu00f8dtker%22%2C%22lastName%22%3A%22Mortensen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f8rge%20Gr%5Cu00f8nne%22%2C%22lastName%22%3A%22Nordestgaard%22%7D%5D%2C%22abstractNote%22%3A%22Objective%20To%20determine%20the%20association%20between%20levels%20of%20low%20density%20lipoprotein%20cholesterol%20%28LDL-C%29%20and%20all%20cause%20mortality%2C%20and%20the%20concentration%20of%20LDL-C%20associated%20with%20the%20lowest%20risk%20of%20all%20cause%20mortality%20in%20the%20general%20population.%5CnDesign%20Prospective%20cohort%20study.%5CnSetting%20Denmark%3B%20the%20Copenhagen%20General%20Population%20Study%20recruited%20in%202003-15%20with%20a%20median%20follow-up%20of%209.4%20years.%5CnParticipants%20Individuals%20randomly%20selected%20from%20the%20national%20Danish%20Civil%20Registration%20System.%5CnMain%20outcome%20measures%20Baseline%20levels%20of%20LDL-C%20associated%20with%20risk%20of%20mortality%20were%20evaluated%20on%20a%20continuous%20scale%20%28restricted%20cubic%20splines%29%20and%20by%20a%20priori%20defined%20centile%20categories%20with%20Cox%20proportional%20hazards%20regression%20models.%20Main%20outcome%20was%20all%20cause%20mortality.%20Secondary%20outcomes%20were%20cause%20specific%20mortality%20%28cardiovascular%2C%20cancer%2C%20and%20other%20mortality%29.%5CnResults%20Among%20108%20243%20individuals%20aged%2020-100%2C%2011%20376%20%2810.5%25%29%20died%20during%20the%20study%2C%20at%20a%20median%20age%20of%2081.%20The%20association%20between%20levels%20of%20LDL-C%20and%20the%20risk%20of%20all%20cause%20mortality%20was%20U%20shaped%2C%20with%20low%20and%20high%20levels%20associated%20with%20an%20increased%20risk%20of%20all%20cause%20mortality.%20Compared%20with%20individuals%20with%20concentrations%20of%20LDL-C%20of%203.4-3.9%20mmol%5C%2FL%20%28132-154%20mg%5C%2FdL%3B%2061st-80th%20centiles%29%2C%20the%20multivariable%20adjusted%20hazard%20ratio%20for%20all%20cause%20mortality%20was%201.25%20%2895%25%20confidence%20interval%201.15%20to%201.36%29%20for%20individuals%20with%20LDL-C%20concentrations%20of%20less%20than%201.8%20mmol%5C%2FL%20%28%3C70%20mg%5C%2FdL%3B%201st-5th%20centiles%29%20and%201.15%20%281.05%20to%201.27%29%20for%20LDL-C%20concentrations%20of%20more%20than%204.8%20mmol%5C%2FL%20%28%3E189%20mg%5C%2FdL%3B%2096th-100th%20centiles%29.%20The%20concentration%20of%20LDL-C%20associated%20with%20the%20lowest%20risk%20of%20all%20cause%20mortality%20was%203.6%20mmol%5C%2FL%20%28140%20mg%5C%2FdL%29%20in%20the%20overall%20population%20and%20in%20individuals%20not%20receiving%20lipid%20lowering%20treatment%2C%20compared%20with%202.3%20mmol%5C%2FL%20%2889%20mg%5C%2FdL%29%20in%20individuals%20receiving%20lipid%20lowering%20treatment.%20Similar%20results%20were%20seen%20in%20men%20and%20women%2C%20across%20age%20groups%2C%20and%20for%20cancer%20and%20other%20mortality%2C%20but%20not%20for%20cardiovascular%20mortality.%20Any%20increase%20in%20LDL-C%20levels%20was%20associated%20with%20an%20increased%20risk%20of%20myocardial%20infarction.%5CnConclusions%20In%20the%20general%20population%2C%20low%20and%20high%20levels%20of%20LDL-C%20were%20associated%20with%20an%20increased%20risk%20of%20all%20cause%20mortality%2C%20and%20the%20lowest%20risk%20of%20all%20cause%20mortality%20was%20found%20at%20an%20LDL-C%20concentration%20of%203.6%20mmol%5C%2FL%20%28140%20mg%5C%2FdL%29.%22%2C%22date%22%3A%222020%5C%2F12%5C%2F08%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmj.m4266%22%2C%22ISSN%22%3A%221756-1833%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.bmj.com%5C%2Fcontent%5C%2F371%5C%2Fbmj.m4266%22%2C%22collections%22%3A%5B%22BVMKAG42%22%5D%2C%22dateModified%22%3A%222023-02-17T17%3A45%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22EMX3NJGJ%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stone%22%2C%22parsedDate%22%3A%221979%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStone%20I.%20Eight%20Decades%20of%20Scurvy%3A%20The%20Case%20History%20of%20a%20Misleading%20Dietary%20Hypothesis.%20Published%20online%201979.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fisom.ca%5C%2Fwp-content%5C%2Fuploads%5C%2F2020%5C%2F01%5C%2FJOM_1979_08_2_01_Eight_Decades_of_Scurvy_The_Case_History-.pdf%27%3Ehttps%3A%5C%2F%5C%2Fisom.ca%5C%2Fwp-content%5C%2Fuploads%5C%2F2020%5C%2F01%5C%2FJOM_1979_08_2_01_Eight_Decades_of_Scurvy_The_Case_History-.pdf%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Eight%20Decades%20of%20Scurvy%3A%20The%20Case%20History%20of%20a%20Misleading%20Dietary%20Hypothesis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irwin%22%2C%22lastName%22%3A%22Stone%22%7D%5D%2C%22abstractNote%22%3A%22The%20document%20%5C%22Eight%20Decades%20of%20Scurvy%3A%20The%20Case%20History%20of%20a%20Misleading%20Dietary%20Hypothesis%5C%22%20is%20a%20historical%20analysis%20of%20the%20scientific%20debate%20around%20the%20cause%20of%20scurvy%2C%20a%20disease%20caused%20by%20a%20deficiency%20of%20vitamin%20C.%20The%20paper%20examines%20the%20development%20of%20the%20%5C%22anti-vitamin%5C%22%20hypothesis%2C%20which%20suggested%20that%20scurvy%20was%20caused%20by%20the%20consumption%20of%20refined%20carbohydrates%20and%20sugar%2C%20rather%20than%20a%20lack%20of%20vitamin%20C.%5Cn%5CnThe%20author%20argues%20that%20the%20anti-vitamin%20hypothesis%20was%20based%20on%20flawed%20research%20and%20biased%20interpretation%20of%20data.%20Despite%20mounting%20evidence%20that%20scurvy%20was%20caused%20by%20a%20lack%20of%20vitamin%20C%2C%20the%20anti-vitamin%20proponents%20were%20able%20to%20maintain%20a%20significant%20influence%20over%20the%20scientific%20community%20for%20many%20years.%20This%20delayed%20the%20implementation%20of%20effective%20treatments%20for%20scurvy%20and%20contributed%20to%20the%20deaths%20of%20countless%20people%20who%20could%20have%20been%20saved%20by%20vitamin%20C%20supplementation.%5Cn%5CnThe%20paper%20concludes%20that%20the%20case%20of%20scurvy%20and%20the%20anti-vitamin%20hypothesis%20serves%20as%20a%20cautionary%20tale%20about%20the%20dangers%20of%20scientific%20dogma%20and%20the%20importance%20of%20open-mindedness%20in%20scientific%20inquiry.%22%2C%22date%22%3A%221979%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fisom.ca%5C%2Fwp-content%5C%2Fuploads%5C%2F2020%5C%2F01%5C%2FJOM_1979_08_2_01_Eight_Decades_of_Scurvy_The_Case_History-.pdf%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-02-15T23%3A04%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22ZCYFNG5H%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Qin%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EQin%20S%2C%20Wang%20G%2C%20Chen%20L%2C%20et%20al.%20Pharmacological%20vitamin%20C%20inhibits%20mTOR%20signaling%20and%20tumor%20growth%20by%20degrading%20Rictor%20and%20inducing%20HMOX1%20expression.%20%3Ci%3EPLOS%20Genetics%3C%5C%2Fi%3E.%202023%3B19%282%29%3Ae1010629.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgen.1010629%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgen.1010629%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pharmacological%20vitamin%20C%20inhibits%20mTOR%20signaling%20and%20tumor%20growth%20by%20degrading%20Rictor%20and%20inducing%20HMOX1%20expression%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Senlin%22%2C%22lastName%22%3A%22Qin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guoyan%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huijun%22%2C%22lastName%22%3A%22Geng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yining%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chao%22%2C%22lastName%22%3A%22Xia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shengru%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junhu%22%2C%22lastName%22%3A%22Yao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lu%22%2C%22lastName%22%3A%22Deng%22%7D%5D%2C%22abstractNote%22%3A%22Pharmacological%20vitamin%20C%20%28VC%29%20is%20a%20potential%20natural%20compound%20for%20cancer%20treatment.%20However%2C%20the%20mechanism%20underlying%20its%20antitumor%20effects%20remains%20unclear.%20In%20this%20study%2C%20we%20found%20that%20pharmacological%20VC%20significantly%20inhibits%20the%20mTOR%20%28including%20mTORC1%20and%20mTORC2%29%20pathway%20activation%20and%20promotes%20GSK3-FBXW7-mediated%20Rictor%20ubiquitination%20and%20degradation%20by%20increasing%20the%20cellular%20ROS.%20Moreover%2C%20we%20identified%20that%20HMOX1%20is%20a%20checkpoint%20for%20pharmacological-VC-mediated%20mTOR%20inactivation%2C%20and%20the%20deletion%20of%20FBXW7%20or%20HMOX1%20suppresses%20the%20regulation%20of%20pharmacological%20VC%20on%20mTOR%20activation%2C%20cell%20size%2C%20cell%20viability%2C%20and%20autophagy.%20More%20importantly%2C%20it%20was%20observed%20that%20the%20inhibition%20of%20mTOR%20by%20pharmacological%20VC%20supplementation%20in%20vivo%20produces%20positive%20therapeutic%20responses%20in%20tumor%20growth%2C%20while%20HMOX1%20deficiency%20rescues%20the%20inhibitory%20effect%20of%20pharmacological%20VC%20on%20tumor%20growth.%20These%20results%20demonstrate%20that%20VC%20influences%20cellular%20activities%20and%20tumor%20growth%20by%20inhibiting%20the%20mTOR%20pathway%20through%20Rictor%20and%20HMOX1%2C%20which%20may%20have%20therapeutic%20potential%20for%20cancer%20treatment.%22%2C%22date%22%3A%22Feb%2014%2C%202023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgen.1010629%22%2C%22ISSN%22%3A%221553-7404%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.plos.org%5C%2Fplosgenetics%5C%2Farticle%3Fid%3D10.1371%5C%2Fjournal.pgen.1010629%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-02-15T19%3A12%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22J9WKEU2R%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yilmaz%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EYilmaz%20G%2C%20Bulut%20H%2C%20Omaygenc%20DO%2C%20et%20al.%20Baseline%20serum%20vitamin%20A%20and%20vitamin%20C%20levels%20and%20their%20association%20with%20disease%20severity%20in%20COVID-19%20patients%3A%20Serum%20Vitamin%20A%20and%20C%20levels%20and%20COVID-19%20severity.%20%3Ci%3EActa%20Biomed%3C%5C%2Fi%3E.%202023%3B94%281%29%3Ae2023007-e2023007.%20%3Ca%20class%3D%27zp-DOIURL%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.23750%5C%2Fabm.v94i1.13655%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.23750%5C%2Fabm.v94i1.13655%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Baseline%20serum%20vitamin%20A%20and%20vitamin%20C%20levels%20and%20their%20association%20with%20disease%20severity%20in%20COVID-19%20patients%3A%20Serum%20Vitamin%20A%20and%20C%20levels%20and%20COVID-19%20severity%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gulseren%22%2C%22lastName%22%3A%22Yilmaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huri%22%2C%22lastName%22%3A%22Bulut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Derya%20Ozden%22%2C%22lastName%22%3A%22Omaygenc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aysu%22%2C%22lastName%22%3A%22Akca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esra%22%2C%22lastName%22%3A%22Can%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nevin%22%2C%22lastName%22%3A%22Tuten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aysegul%22%2C%22lastName%22%3A%22Bestel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baki%22%2C%22lastName%22%3A%22Erdem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uygar%20Ozan%22%2C%22lastName%22%3A%22Atmaca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasin%22%2C%22lastName%22%3A%22Kara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ebru%22%2C%22lastName%22%3A%22Kaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Murat%22%2C%22lastName%22%3A%22Unsel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayca%20Sultan%22%2C%22lastName%22%3A%22Sahin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ziya%22%2C%22lastName%22%3A%22Salihoglu%22%7D%5D%2C%22abstractNote%22%3A%22Aim%3A%5Cu00a0We%20aimed%20to%20investigate%20the%20association%20between%20the%20serum%20concentrations%20of%20Vitamin%20A%20and%20Vitamin%20C%20and%20the%20severity%20of%20the%20COVID-19.%5Cu00a0%5CnMethods%3A%5Cu00a0Fifty-three%20consecutive%20PCR%20%28%2B%29%20COVID-19%20patients%20admitted%20to%20a%20dedicated%20ward%20were%20enrolled%20in%20this%20study.%20Blood%20samples%20for%20serum%20Vitamin%20A%20and%20C%20measurements%20were%20drawn%20from%20all%20participants%20upon%20admission.%20All%20subjects%20underwent%20thoracic%20CT%20imaging%20prior%20to%20hospitalization.%20CT%20severity%20score%20%28CT-SS%29%20was%20then%20calculated%20for%20determining%20the%20extent%20of%20pulmonary%20involvement.%20A%20group%20of%20healthy%20volunteers%2C%20in%20whom%20COVID-19%20was%20ruled%20out%2C%20were%20assigned%20to%20the%20control%20group%20%28n%3D26%29.%20These%20groups%20were%20compared%20by%20demographic%20features%20and%20serum%20vitamin%20A%20and%20C%20levels.%20The%20relationship%20between%20serum%20concentrations%20of%20these%20vitamins%20and%20pre-defined%20outcome%20measures%2C%20CT-SS%20and%20length%20of%20hospitalization%20%28LOH%29%2C%20was%20also%20assessed.%5Cu00a0%5CnResults%3A%5Cu00a0In%20COVID-19%20patients%2C%20serum%20Vitamin%20A%20%28ng%5C%2Fml%2C%20494%5Cu00b196%20vs.%20698%5Cu00b193%3B%20p%3C0.001%29%20and%20Vitamin%20C%20%28ng%5C%2Fml%2C%202961%20%5B1991-31718%5D%20vs.%203953%20%5B1385-8779%5D%3B%20p%3D0.007%29%20levels%20were%20significantly%20lower%20with%20respect%20to%20healthy%20controls.%20According%20to%20the%20results%20of%20correlation%20analyses%2C%20there%20was%20a%20significant%20negative%20association%20between%20Vitamin%20A%20level%20and%20outcome%20measures%20%28LOH%2C%20r%3D-0.293%3B%20p%3D0.009%20and%20CT-SS%2C%20r%3D-0.289%3B%20p%3D0.010%29.%20The%20negative%20correlations%20between%20Vitamin%20C%20level%20and%20those%20measures%20were%20even%20more%20prominent%20%28LOH%2C%20r%3D-0.478%3B%20p%3C0.001%20and%20CT-SS%2C%20r%3D-0.734%3A%20p%3C0.001%29.%5CnConclusion%3A%5Cu00a0COVID-19%20patients%20had%20lower%20baseline%20serum%20Vitamin%20A%20and%20Vitamin%20C%20levels%20as%20compared%20to%20healthy%20controls.%20In%20subjects%20with%20COVID-19%2C%20Vitamin%20A%20and%20Vitamin%20C%20levels%20were%20negatively%20correlated%20with%20CT-SS%20and%20LOH.%22%2C%22date%22%3A%222023%5C%2F02%5C%2F13%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.23750%5C%2Fabm.v94i1.13655%22%2C%22ISSN%22%3A%222531-6745%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fmattioli1885journals.com%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-02-14T21%3A58%3A52Z%22%7D%7D%2C%7B%22key%22%3A%224U6ETN3V%22%2C%22library%22%3A%7B%22id%22%3A10725819%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cai%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ECai%20Y%2C%20Zhong%20Y%20di%2C%20Zhang%20H%2C%20et%20al.%20Association%20between%20dietary%20vitamin%20C%20and%20telomere%20length%3A%20A%20cross-sectional%20study.%20%3Ci%3EFrontiers%20in%20Nutrition%3C%5C%2Fi%3E.%202023%3B10.%20Accessed%20February%2013%2C%202023.%20%3Ca%20class%3D%27zp-ItemURL%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1025936%27%3Ehttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1025936%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20dietary%20vitamin%20C%20and%20telomere%20length%3A%20A%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuan%22%2C%22lastName%22%3A%22Cai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu-di%22%2C%22lastName%22%3A%22Zhong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hao%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pei-lin%22%2C%22lastName%22%3A%22Lu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yong-yi%22%2C%22lastName%22%3A%22Liang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Biao%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hui%22%2C%22lastName%22%3A%22Wu%22%7D%5D%2C%22abstractNote%22%3A%22BackgroundCurrently%2C%20telomere%20length%20is%20known%20to%20reflect%20the%20replication%20potential%20and%20longevity%20of%20cells%2C%20and%20many%20studies%20have%20reported%20that%20telomere%20length%20is%20associated%20with%20age-related%20diseases%20and%20biological%20aging.%20Studies%20have%20also%20shown%20that%20vitamin%20C%20acts%20as%20an%20oxidant%20and%20free%20radical%20scavenger%20to%20protect%20cells%20from%20oxidative%20stress%20and%20telomere%20wear%2C%20thus%20achieving%20anti-aging%20effects.%20At%20present%2C%20there%20are%20few%20and%20incomplete%20studies%20on%20the%20relationship%20between%20vitamin%20C%20and%20telomere%20length%2C%20so%20this%20study%20aims%20to%20explore%20the%20relationship%20between%20vitamin%20C%20and%20telomere%20length.MethodsThis%20study%20used%20cross-sectional%20data%20from%20the%20National%20Health%20and%20Nutrition%20Examination%20Surveys%20%28NHANES%29%20database%20from%201999%20to%202002%2C%20a%20total%20of%207%2C094%20participants%20were%20selected%20from%20all%20races%20in%20the%20United%20States.%20Male%20participants%20accounted%20for%2048.2%25%20and%20female%20participants%20accounted%20for%2051.8%25.%20The%20correlation%20between%20vitamin%20C%20and%20telomere%20length%20was%20assessed%20using%20a%20multiple%20linear%20regression%20model%2C%20and%20the%20effect%20of%20dietary%20vitamin%20C%20on%20telomere%20length%20was%20obtained%20after%20adjusting%20for%20confounding%20factors%20such%20as%20age%2C%20gender%2C%20race%2C%20body%20mass%20index%20%28BMI%29%2C%20and%20poverty%20income%20ratio%20%28PIR%29.ResultsThis%20cross-sectional%20study%20showed%20that%20vitamin%20C%20was%20positively%20correlated%20with%20telomere%20length%2C%20with%20greater%20dietary%20vitamin%20C%20intake%20associated%20with%20longer%20telomeres%20%28%5Cu03b2%20%3D%200.03%2C%2095%25%20CI%3A%200.01%5Cu20130.05%2C%20P%20%3D%200.003%29.ConclusionThis%20study%20shows%20that%20vitamin%20C%20intake%20is%20positively%20correlated%20with%20human%20telomere%20length%2C%20which%20is%20of%20guiding%20significance%20for%20our%20clinical%20guidance%20on%20people%5Cu2019s%20health%20care%2C%20but%20our%20study%20need%20to%20be%20confirmed%20by%20more%20in-depth%20and%20comprehensive%20other%20research%20results.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222296-861X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnut.2023.1025936%22%2C%22collections%22%3A%5B%22VFY3LYPC%22%5D%2C%22dateModified%22%3A%222023-02-13T18%3A44%3A31Z%22%7D%7D%5D%7D
1.
Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration—Neurodegenerative Disease - PMC. Accessed January 22, 2024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874683/
1.
Cooper ID, Sanchez-Pizarro C, Norwitz NG, et al. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model. Frontiers in Endocrinology. 2023;14. Accessed December 21, 2023. https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768
1.
Hemilä H, Chalker E. Vitamin C reduces the severity of common colds: a meta-analysis. BMC Public Health. 2023;23(1):2468. http://doi.org/10.1186/s12889-023-17229-8
1.
Norwitz NG, Mindrum MR, Giral P, et al. Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022;16(6):765-768. http://doi.org/10.1016/j.jacl.2022.10.010
1.
Soltani S, Jayedi A, Abdollahi S, Vasmehjani AA, Meshkini F, Shab-Bidar S. Effect of carbohydrate restriction on body weight in overweight and obese adults: a systematic review and dose–response meta-analysis of 110 randomized controlled trials. Frontiers in Nutrition. 2023;10. Accessed December 7, 2023. https://www.frontiersin.org/articles/10.3389/fnut.2023.1287987
1.
Rouleau L, Antony AN, Bisetto S, et al. Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity. Free Radic Biol Med. 2016;95:308-322. http://doi.org/10.1016/j.freeradbiomed.2016.03.031
1.
Gomez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. The American Journal of Clinical Nutrition. 2008;87(1):142-149. http://doi.org/10.1093/ajcn/87.1.142
1.
Vitamin C and Colds. WebMD. Accessed December 6, 2022. https://www.webmd.com/cold-and-flu/cold-guide/vitamin-c-for-common-cold
1.
Zarakowska E, Guz J, Mijewski P, et al. Intracellular ascorbate is a safe-guard and/or reservoir for plasma vitamin C in prostate cancer patients undergoing radiotherapy. Free Radical Biology and Medicine. Published online November 29, 2023. http://doi.org/10.1016/j.freeradbiomed.2023.11.024
1.
Zhao X, Liu M, Li C, et al. High dose Vitamin C inhibits PD-L1 by ROS-pSTAT3 signal pathway and enhances T cell function in TNBC. Int Immunopharmacol. 2023;126:111321. http://doi.org/10.1016/j.intimp.2023.111321
1.
Intravenous Vitamin C Supplementation in Allogeneic Hematopoietic Cell Transplant Recipients: Salutary Impact on Clinical Outcomes. doi:10.21203/rs.3.rs-3538792/v1
1.
Toor A, Simmons G, Sabo R, et al. Intravenous Vitamin C Supplementation in Allogeneic Hematopoietic Cell Transplant Recipients: Salutary Impact on Clinical Outcomes. Res Sq. Published online November 10, 2023:rs.3.rs-3538792. http://doi.org/10.21203/rs.3.rs-3538792/v1
1.
Lykkesfeldt J, Carr AC. Vitamin C1. Advances in Nutrition. Published online November 21, 2023:100155. http://doi.org/10.1016/j.advnut.2023.100155
1.
Beglaryan N, Hakobyan G, Nazaretyan E. Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress. Stress and Health. n/a(n/a). http://doi.org/10.1002/smi.3347
1.
Moreno-Macias H, Romieu I. Effects of antioxidant supplements and nutrients on patients with asthma and allergies. Journal of Allergy and Clinical Immunology. 2014;133(5):1237-1244. http://doi.org/10.1016/j.jaci.2014.03.020
1.
Ramón R, Holguín E, Chiriboga JD, Rubio N, Ballesteros C, Ezechieli M. Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial. J Pers Med. 2023;13(9):1299. http://doi.org/10.3390/jpm13091299
1.
Knorr AL, Wexler RS, Fuller L. Treatment of Epstein-Barr Induced Hepatitis with High Dose Intravenous Vitamin C: A Case Report. Integr Med (Encinitas). 2023;22(4):24-27.
1.
Zeng Y, Liu Z, Xu F, Tang Z. Intravenous high-dose vitamin C monotherapy for sepsis and septic shock: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2023;102(42):e35648. http://doi.org/10.1097/MD.0000000000035648
1.
Hashemi SA, Ghadimi Z, Ghaedi H, Hashemi A. The effects of eight weeks of aerobic training with vitamin C on the expression pathway of antioxidants in the hippocampus tissue of TMT induced Alzheimer’s disease rats. Brain Res. 2023;1822:148645. http://doi.org/10.1016/j.brainres.2023.148645
1.
Lankadeva YR, Lane DJR, Ow CPC, Story DA, Plummer MP, May CN. LOVIT or leave it: The vitamin C debate continues. Crit Care Resusc. 2023;25(2):63-64. http://doi.org/10.1016/j.ccrj.2023.05.001
1.
Lankadeva YR, Lane DJ, Ow CP, Story DA, Plummer MP, May CN. LOVIT or leave it: The vitamin C debate continues. Crit Care Resusc. 2023;25(2):63-64. http://doi.org/10.1016/j.ccrj.2023.05.001
1.
Hickey S, Roberts H. Misleading Information on the Properties of Vitamin C. PLoS Medicine. 2005;2(9). http://doi.org/10.1371/journal.pmed.0020307
1.
Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews. 2013;(1). http://doi.org/10.1002/14651858.CD000980.pub4
1.
Ran L, Zhao W, Wang J, et al. Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials. Biomed Res Int. Published online July 5, 2018:1837634. http://doi.org/10.1155/2018/1837634
1.
Cathcart R. The Method of Determining Proper Doses of Vitamin C for the Treatment of Disease by Titrating to Bowel Tolerance. Journal of Orthomolecular Psychiatry. 1981;10(2):125-132.
1.
DeGeorge KC, Ring DJ, Dalrymple SN. Treatment of the Common Cold. afp. 2019;100(5):281-289. Accessed January 16, 2023. https://www.aafp.org/pubs/afp/issues/2019/0901/p281.html
1.
Optical stimulation of mitochondria reduces blood glucose levels. doi:10.21203/rs.3.rs-3275287/v1
1.
Aronica L, Landry MJ, Rigdon J, Gardner CD. Weight, insulin resistance, blood lipids, and diet quality changes associated with ketogenic and ultra low-fat dietary patterns: a secondary analysis of the DIETFITS randomized clinical trial. Frontiers in Nutrition. 2023;10. Accessed July 13, 2023. https://www.frontiersin.org/articles/10.3389/fnut.2023.1220020
1.
Diamond DM, Bikman BT, Mason P. Statin therapy is not warranted for a person with high LDL-cholesterol on a low-carbohydrate diet. Current Opinion in Endocrinology, Diabetes and Obesity. 2022;29(5):497. Accessed June 25, 2023. https://journals.lww.com/co-endocrinology/Fulltext/2022/10000/Statin_therapy_is_not_warranted_for_a_person_with.14.aspx
1.
McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. The Journal of Steroid Biochemistry and Molecular Biology. 2019;189:228-239. http://doi.org/10.1016/j.jsbmb.2018.12.010
1.
McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. The Journal of Steroid Biochemistry and Molecular Biology. 2019;189:228-239. http://doi.org/10.1016/j.jsbmb.2018.12.010
1.
Amzali S, Wilson VD, Bommart S, et al. Nutritional Status of Patients with Facioscapulohumeral Muscular Dystrophy. Nutrients. 2023;15(7):1673. http://doi.org/10.3390/nu15071673
1.
Hung KC, Chuang MH, Chen JY, et al. Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: A meta-analysis of randomized controlled trials with trial sequential analysis. Front Nutr. 2023;10:1094757. http://doi.org/10.3389/fnut.2023.1094757
1.
Marcec R, Posavec F, Likic R. Vitamin C utilisation in 2020: have we bought a lemon? Postgraduate Medical Journal. 2022;98(1163):651-652. http://doi.org/10.1136/pmj-2022-141978
1.
Coskun N, Altinay M, Turk HS, et al. The effect of High-Dose Vitamin C Treatment for Acute Respiratory Failure Due to Coronavirus Disease Pneumonia on Mortality and Length of Intensive Care Stay: A Retrospective Cohort Study. Sisli Etfal Hastan Tip Bul. 2023;57(1):25-32. http://doi.org/10.14744/SEMB.2022.66742
1.
Hassuna NA, Rabie EM, Mahd WKM, Refaie MMM, Yousef RKM, Abdelraheem WM. Antibacterial effect of vitamin C against uropathogenic E. coli in vitro and in vivo. BMC Microbiol. 2023;23(1):112. http://doi.org/10.1186/s12866-023-02856-3
1.
Volek JS, Phinney SD, Krauss RM, et al. Alternative Dietary Patterns for Americans: Low-Carbohydrate Diets. Nutrients. 2021;13(10):3299. http://doi.org/10.3390/nu13103299
1.
Sampson HA. Food allergy: Past, present and future. Allergology International. 2016;65(4):363-369. http://doi.org/10.1016/j.alit.2016.08.006
1.
Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. http://doi.org/10.1177/1177271918785130
1.
Liang B, Su J, Shao H, Chen H, Xie B. The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials. Crit Care. 2023;27:109. http://doi.org/10.1186/s13054-023-04392-y
1.
Lbban E, Ashor A, Shannon OM, Idris I, Siervo M. Is vitamin C a booster of the effects of dietary nitrate on endothelial function? Physiologic rationale and implications for research. Nutrition. 2023;109:111995. http://doi.org/10.1016/j.nut.2023.111995
1.
Jefferson T, Dooley L, Ferroni E, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Acute Respiratory Infections Group, ed. Cochrane Database of Systematic Reviews. 2023;2023(1). http://doi.org/10.1002/14651858.CD006207.pub6
1.
Kearns CE, Schmidt LA, Glantz SA. Sugar Industry and Coronary Heart Disease Research: A Historical Analysis of Internal Industry Documents. JAMA Internal Medicine. 2016;176(11):1680-1685. http://doi.org/10.1001/jamainternmed.2016.5394
1.
Feinman RD, Pogozelski WK, Astrup A, et al. Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. Nutrition. 2015;31(1):1-13. http://doi.org/10.1016/j.nut.2014.06.011
1.
Labbani-Motlagh Z, Amini S, Aliannejad R, et al. High-dose Intravenous Vitamin C in Early Stages of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Double-blind, Randomized, Controlled Clinical Trial. J Res Pharm Pract. 2022;11(2):64-72. http://doi.org/10.4103/jrpp.jrpp_30_22
1.
Johannesen CDL, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. BMJ. 2020;371:m4266. http://doi.org/10.1136/bmj.m4266
1.
Stone I. Eight Decades of Scurvy: The Case History of a Misleading Dietary Hypothesis. Published online 1979. https://isom.ca/wp-content/uploads/2020/01/JOM_1979_08_2_01_Eight_Decades_of_Scurvy_The_Case_History-.pdf
1.
Qin S, Wang G, Chen L, et al. Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression. PLOS Genetics. 2023;19(2):e1010629. http://doi.org/10.1371/journal.pgen.1010629
1.
Yilmaz G, Bulut H, Omaygenc DO, et al. Baseline serum vitamin A and vitamin C levels and their association with disease severity in COVID-19 patients: Serum Vitamin A and C levels and COVID-19 severity. Acta Biomed. 2023;94(1):e2023007-e2023007. http://doi.org/10.23750/abm.v94i1.13655
1.
Cai Y, Zhong Y di, Zhang H, et al. Association between dietary vitamin C and telomere length: A cross-sectional study. Frontiers in Nutrition. 2023;10. Accessed February 13, 2023. https://www.frontiersin.org/articles/10.3389/fnut.2023.1025936